ZP4
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Official Full Name
zona pellucida glycoprotein 4 -
Overview
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. -
Synonyms
ZP4;zona pellucida glycoprotein 4;zona pellucida sperm-binding protein 4;ZPB;zona pellucida B protein;zona pellucida protein B;ZBP;ZP1;Zp-4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| ZP4-1113C | Recombinant Cynomolgus ZP4 Protein, His-tagged | Mammalian Cells | Cynomolgus | His |
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| ZP4-6442C | Recombinant Chicken ZP4 | Mammalian Cells | Chicken | His |
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| RFL24167OF | Recombinant Full Length Rabbit Zona Pellucida Sperm-Binding Protein 4(Zp4) Protein, His-Tagged | E.coli | Oryctolagus cuniculus (Rabbit) | His | Full L. Full Length of Mature Protein (25-466) |
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| RFL8451FF | Recombinant Full Length Cat Zona Pellucida Sperm-Binding Protein 4(Zp4) Protein, His-Tagged | E.coli | Felis catus | His | Full L. Full Length of Mature Protein (20-496) |
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| ZP4-856C | Recombinant Cynomolgus Monkey ZP4 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| ZP4-856C-B | Recombinant Cynomolgus Monkey ZP4 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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Involved Pathway
ZP4 involved in several pathways and played different roles in them. We selected most pathways ZP4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
ZP4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ZP4 itself. We selected most functions ZP4 had, and list some proteins which have the same functions with ZP4. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
ZP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZP4.
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References
- Petit, FM; Serres, C; et al. Moonlighting proteins in sperm-egg interactions. BIOCHEMICAL SOCIETY TRANSACTIONS 42:1740-1743(2014).
- Avella, MA; Baibakov, B; et al. A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans. JOURNAL OF CELL BIOLOGY 205:801-809(2014).
