ZNRF1
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Official Full Name
zinc and ring finger 1, E3 ubiquitin protein ligase -
Overview
In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene. -
Synonyms
ZNRF1;zinc and ring finger 1, E3 ubiquitin protein ligase;zinc and ring finger 1;E3 ubiquitin-protein ligase ZNRF1;DKFZp434E229;FLJ14846;nin283;nerve injury gene 283;zinc/RING finger protein 1;zinc and ring finger protein 1;nerve injury-induced
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZNRF1-3880H | Recombinant Human ZNRF1, His-tagged | E.coli | Human | His | 4-143aa | |
| ZNRF1-11118Z | Recombinant Zebrafish ZNRF1 | Mammalian Cells | Zebrafish | His |
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| ZNRF1-134H | Recombinant Human ZNRF1, GST-tagged | E.coli | Human | GST | 1-227 a.a. |
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| ZNRF1-19219M | Recombinant Mouse ZNRF1 Protein | Mammalian Cells | Mouse | His |
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| ZNRF1-443H | Recombinant Human ZNRF1 Protein, His-tagged | E.coli | Human | His |
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| ZNRF1-5371R | Recombinant Rhesus monkey ZNRF1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| ZNRF1-2097HCL | Recombinant Human ZNRF1 cell lysate | Human | Non |
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| ZNRF1-10491M | Recombinant Mouse ZNRF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ZNRF1-10491M-B | Recombinant Mouse ZNRF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ZNRF1-5184R | Recombinant Rhesus Macaque ZNRF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ZNRF1-5184R-B | Recombinant Rhesus Macaque ZNRF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ZNRF1 involved in several pathways and played different roles in them. We selected most pathways ZNRF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ZNRF1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNRF1 itself. We selected most functions ZNRF1 had, and list some proteins which have the same functions with ZNRF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | RNF19A,UBE2S,WWP2,RNF111,PJA2,UBE2G1,UBE3B,ZNRF2,RNF41,TRIM59 |
| zinc ion binding | TRIM47,CHD4A,PTER,ABLIM1A,ZDHHC23,MYCBP2,TRIM25,UBR2,ZNF346,CAR5A |
| ligase activity | G2E3,TRIM4,RNF20,TRIM6,WWP2,CTPS1A,WWP1,MSL2,RNF220,LNX1 |
| ubiquitin-protein transferase activity | TRIM2,MUL1A,LNX2B,FBXO25,FANCL,ANKIB1,RNF217,UBE2L6,MARCH5L,UBA7 |
| protein binding | CNOT2,TAX1BP3,MYO5B,RBMY1A1,NIPSNAP3A,APOA1,SDCBP,KRTAP12-2,DNAJC11,LIMD1 |
Interacting Protein
ZNRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNRF1.
UBE2D1;UBE2D2;UBE2E1;UBE2D3;UBE2N;UBE2D4
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References
- Stinton, LM; Myers, RP; et al. Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection. BMC GASTROENTEROLOGY 13:-(2013).
- Xiong, R; Nie, L; et al. Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution. JOURNAL OF IMMUNOLOGY 188:2653-2668(2012).
