ZMPSTE24
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Official Full Name
zinc metallopeptidase STE24 homolog -
Overview
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. -
Synonyms
ZMPSTE24;zinc metallopeptidase STE24 homolog (S. cerevisiae);zinc metallopeptidase (STE24 homolog, yeast) , zinc metalloproteinase (STE24 homolog, yeast);CAAX prenyl protease 1 homolog;FACE 1;HGPS;Hutchinson Gilford progeria syndrome;PRO1;STE24
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Mus musculus
- Human
- Dictyostelium Discoideum
- Mammalian Cells
- E.coli
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZMPSTE24-10263Z | Recombinant Zebrafish ZMPSTE24 | Mammalian Cells | Zebrafish | His |
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| ZMPSTE24-5298R | Recombinant Rhesus monkey ZMPSTE24 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| RFL14977MF | Recombinant Full Length Mouse Caax Prenyl Protease 1 Homolog(Zmpste24) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-475) |
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| RFL15990HF | Recombinant Full Length Human Caax Prenyl Protease 1 Homolog(Zmpste24) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-475) |
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| RFL32216DF | Recombinant Full Length Dictyostelium Discoideum Caax Prenyl Protease 1 Homolog(Zmpste24) Protein, His-Tagged | E.coli | Dictyostelium Discoideum | His | Full L. Full Length (1-426) |
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| ZMPSTE24-5111R | Recombinant Rhesus Macaque ZMPSTE24 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ZMPSTE24-5111R-B | Recombinant Rhesus Macaque ZMPSTE24 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ZMPSTE24 involved in several pathways and played different roles in them. We selected most pathways ZMPSTE24 participated on our site, such as Terpenoid backbone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZMPSTE24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Terpenoid backbone biosynthesis | MVD,PDSS2,ACAT1,ICMT,DHDDS,HMGCRB,FDPS,IDI1,PDSS1,NUS1 |
Protein Function
ZMPSTE24 has several biochemical functions, for example, metalloendopeptidase activity,peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZMPSTE24 itself. We selected most functions ZMPSTE24 had, and list some proteins which have the same functions with ZMPSTE24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | PHEX,HE2,ADAMTS2,ADAMTS5,ADAM2,ADAMTS7,ADAM17A,ADAMDEC1,FAP,ADAMTS8 |
| peptidase activity | FAM49BA,SPCS3,USP2A,KLK1B1,CTSL.1,CAPN1B,CAPN5A,TMPRSS11G,DHH,CPD |
Interacting Protein
ZMPSTE24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZMPSTE24 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZMPSTE24.
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