ZIC1
-
Official Full Name
Zic family member 1 -
Overview
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] -
Synonyms
ZIC1;Zic family member 1;ZIC;ZNF201;zinc finger protein ZIC 1;zinc finger protein 201;Zinc finger protein of the cerebellum 1;Zic family member 1 (odd-paired homolog, Drosophila)
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZIC1-19176M | Recombinant Mouse ZIC1 Protein | Mammalian Cell | Mouse | His |
|
|
| ZIC1-31656TH | Recombinant Human ZIC1 | Wheat Germ | Human | Non | 94 amino acids |
|
| ZIC1-5827C | Recombinant Chicken ZIC1 | Mammalian Cell | Chicken | His |
|
|
| ZIC1-8574Z | Recombinant Zebrafish ZIC1 | Mammalian Cell | Zebrafish | His |
|
|
| ZIC1-10379M | Recombinant Mouse ZIC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| ZIC1-10379M-B | Recombinant Mouse ZIC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| ZIC1-440H | Recombinant Human ZIC1 Protein, His-tagged | E.coli | Human | His |
|
Involved Pathway
ZIC1 involved in several pathways and played different roles in them. We selected most pathways ZIC1 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neural Crest Differentiation | TFAP2A,TBX6,DLX5,SOX5,CTBP2,DCT,DLL3,FOXD3,PRTG,LHX2 |
Protein Function
ZIC1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,metal ion binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC1 itself. We selected most functions ZIC1 had, and list some proteins which have the same functions with ZIC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | JUN,TFE3B,BCL11B,NFAT5,ELF1,CREB3,GCM1,E2F4,ONECUT1,EBF3A |
| transcription factor activity, sequence-specific DNA binding | NR2C2,KLF12,GATAD2AB,NKX2-1,ATF6B,HOXB5B,NFE2L1,ZIC2,ZNF302,MLLT10 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | JUND,NR5A2,JUNB,NFATC4,ATOH1,RFX6,HOXA7,DDN,ZNF92,SFPI1 |
| metal ion binding | ZXDB,CLCA5,ADK,GNS,HNRNPA0L,NME4,RXRGB,ZNF670,S100S,ZFP830 |
Interacting Protein
ZIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC1.
Resources
Research Area
Somite MarkersNeural Stem Cell Transcription Factors
Neural Stem Cell Markers
Adipogenesis Markers
Related Services
Related Products
References
- Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).
- Degreef, I; De Smet, L; et al. Immunohistochemical evidence for Zic1 coexpression with -catenin in the myofibroblast of Dupuytren disease. SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY 43:36-40(2009).
