ZAP70
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Official Full Name
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -
Synonyms
ZAP70;zeta-chain (TCR) associated protein kinase 70kDa;SRK, zeta chain (TCR) associated protein kinase (70 kD);tyrosine-protein kinase ZAP-70;STD;ZAP 70;syk-related tyrosine kinase;70 kDa zeta-associated protein;70 kDa zeta-chain associated protein;zeta-chain associated protein kinase, 70kD;SRK;FLJ17670;FLJ17679;ZAP70;zeta-chain (TCR) associated protein kinase 70kDa;TZK;Tyrosine-protein kinase ZAP-70;70 kDa zeta-associated protein Syk-related tyrosine kinase;EC 2.7.10.2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Insect cells
- Mammalian Cells
- Sf9 Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- Avi&Fc&His
- His&T7
- DDK&Myc
- Flag
Involved Pathway
ZAP70 involved in several pathways and played different roles in them. We selected most pathways ZAP70 participated on our site, such as Ras signaling pathway,NF-kappa B signaling pathway,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZAP70 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | FGF22,GNB3,NFKB1,ANGPT1,FGFR3,SHC3,RAC3,FGF19,RASA3,RASSF1 |
| Natural killer cell mediated cytotoxicity | IFNA7,BID,IFNA5,KLRD1,HLA-G,IFNG,MAPK3,SH2D1B,TNFRSF10A,IFNA1 |
| T cell receptor signaling pathway | MAPK1,VAV2,DLG1,CD40LG,NFATC1,CDC42,SLA1,Il2,MUC1,PPP3CB |
| nodeficiency | CD19,TAP2,ICOS,LCK,CD8B,AICDA,BTK,CD79A,RFXANK,IL7R |
| NF-kappa B signaling pathway | TNFSF13B,TRAF6,BCL10,PIAS4,IL-8,TRAF1,IL1R1,IKBKB,NFKBIA,CCL4L2 |
| Primary i | ORAI1,PTPRC,CD3D,RAG2,TAP1,IL2RG,RAG1,AIRE,RFX5,ICOS |
Protein Function
ZAP70 has several biochemical functions, for example, ATP binding,non-membrane spanning protein tyrosine kinase activity,phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZAP70 itself. We selected most functions ZAP70 had, and list some proteins which have the same functions with ZAP70. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphotyrosine binding | GRB2,CBLB,PTPN3,MAPK3,MAPK1,SAMSN1,FGR,CBL,LDLRAP1,CBLC |
| receptor binding | WNT7AA,PTK2BB,SMARCD1,CD2,Artn,GFRA1,POU2F1,LEPROT,RIPK2,NRG2 |
| protein tyrosine kinase activity | ABL2,FGFR1OP,HCK,KITB,CAMKK2,CLK4,PTK2BB,EPHB4A,YES1,FGFR2 |
| protein binding | RIC8,OSBPL3,CDCA8,NPPA,CYTH2,GIT2,EGR1,SPAG9,BLZF1,MSTN |
| non-membrane spanning protein tyrosine kinase activity | YES1,ITK,DYRK1A,TNK2B,PTK2AA,TNK1,FGR,ZNF143B,YRK,JAK2A |
| ATP binding | ADCY3,NLRP4B,MYH3,ATP6V1AA,STK4,PKMYT1,CHEK1,YES1,PRPF4BB,ABCB7 |
Interacting Protein
ZAP70 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZAP70 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZAP70.
CD247
Resources
Research Area
Intracellular Kinases in the Akt PathwayNatural Killer T (NKT) Cells
T Cell Cytokine Signaling
Related Services
Related Products
References
- Ho, KC; Chiang, YJ; et al. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. CELL DEATH & DISEASE 5:-(2014).
- Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
