ZACN
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Official Full Name
zinc activated ligand-gated ion channel -
Overview
LGICZ1 is a zinc-activated ligand-gated ion channel that defines a new subgroup of the cysteine-loop superfamily of;ligand-gated ion channels (Davies et al., 2003 (PubMed 12381728)). -
Synonyms
ZACN;zinc activated ligand-gated ion channel;LGICZ1, ligand gated ion channel, zinc activated 1;zinc-activated ligand-gated ion channel;L2;LGICZ;ZAC;ZAC1;Ligand gated ion channel receptor L2;Ligand gated ion channel zinc activated 1;Zinc activated ligand gated ion channel;ligand-gated ion channel subunit;ligand-gated ion-channel receptor L2;ligand-gated ion channel zinc-activated 1;zinc activated ligand-gated ion channel 1;ligand-gated ion channel, zinc activated 1;LGICZ1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ZACN-226HCL | Recombinant Human ZACN 293 Cell Lysate | HEK293 | Human | Non |
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| RFL28708CF | Recombinant Full Length Dog Zinc-Activated Ligand-Gated Ion Channel(Zacn) Protein, His-Tagged | E.coli expression system | Dog | His | Full L. Full Length of Mature Protein (19-409) |
|
| RFL33234HF | Recombinant Full Length Human Zinc-Activated Ligand-Gated Ion Channel(Zacn) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (26-412) |
|
Involved Pathway
ZACN involved in several pathways and played different roles in them. We selected most pathways ZACN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ZACN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ZACN has several biochemical functions, for example, contributes_to acetylcholine binding,contributes_to acetylcholine receptor activity,contributes_to acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZACN itself. We selected most functions ZACN had, and list some proteins which have the same functions with ZACN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | PHC2B,BTR02,UBR4,NR1H3,TRIM35-24,AEBP1,KMT2E,NR5A1,EHMT1B,KDM1B |
| ligand-gated ion channel activity | CHRNB1,ANXA6,TRPA1B,CLCA2,CHRNA3,CHRNA5,Chrng,CHRNB4,P2RX2,GABRB1 |
| contributes_to acetylcholine-activated cation-selective channel activity | CHRNB3A,CHRNA10A,CHRFAM7A,CHRNA9,CHRNB1L,CHRNB3B,CHRNA2A,CHRNA4B,CHRNA10,CHRNB1 |
| contributes_to acetylcholine binding | CHRNB4,CHRNA10,CHRNA10A,CHRNB3A,CHRNB1,CHRNA6,CHRND,CHRNA5,CHRNA3,CHRNA9 |
| contributes_to acetylcholine receptor activity | CHRNB3A,CHRNA1,CHRNA9,CHRNA4B,CHRNB1,CHRNB1L,CHRNA10,CHRFAM7A,CHRNA10A,CHRND |
Interacting Protein
ZACN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZACN here. Most of them are supplied by our site. Hope this information will be useful for your research of ZACN.
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References
- Stojilkovic, SS; Leiva-Salcedo, E; et al. Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins. ANTIOXIDANTS & REDOX SIGNALING 21:953-970(2014).
- Choi, UB; Kazi, R; et al. Modulating the Intrinsic Disorder in the Cytoplasmic Domain Alters the Biological Activity of the N-Methyl-D-aspartate-sensitive Glutamate Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY 288:22506-22515(2013).
