XYLT1
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Official Full Name
xylosyltransferase I -
Overview
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum. -
Synonyms
XYLT1;xylosyltransferase I;xylosyltransferase 1;protein xylosyltransferase 1;PXYLT1;XT I;xylT-I;O-xylosyltransferase 1;xylosyltransferase iota;beta-D-xylosyltransferase 1;peptide O-xylosyltransferase 1;XT1;XTI;XT-I;XYLTI
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XYLT1-7678Z | Recombinant Zebrafish XYLT1 | Mammalian Cells | Zebrafish | His |
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| XYLT1-1709H | Recombinant Human XYLT1 protein, His & T7-tagged | E.coli | Human | His&T7 | Gly773~Val910 |
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| Xylt1-1710M | Recombinant Mouse Xylt1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Lys716~Gly954 |
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| XYLT1-6264H | Recombinant Human XYLT1 Protein (Gly773-Val910), N-His tagged | E.coli | Human | His | Gly773-Val910 |
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Involved Pathway
XYLT1 involved in several pathways and played different roles in them. We selected most pathways XYLT1 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate,Glycosaminoglycan biosynthesis - heparan sulfate / heparin,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with XYLT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALDH1A3,CBR1L,FLAD1,ACSL3A,NADKB,ATP6V0A2,PNMT,AHCY,OTC,PHOSPHO1 |
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | CSGALNACT1,CHPF,CHPF2,CHSY1,CHST3B,DSE,CHST7,CHST3A,CHST12A,CHST11 |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | EXT1C,EXTL2,B3GAT3,HS6ST1,XYLT2,HS6ST3,GLCEA,EXT1B,NDST2,HS6ST1B |
Protein Function
XYLT1 has several biochemical functions, for example, acetylglucosaminyltransferase activity,protein xylosyltransferase activity,transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XYLT1 itself. We selected most functions XYLT1 had, and list some proteins which have the same functions with XYLT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein xylosyltransferase activity | XYLT2,POGLUT1 |
| acetylglucosaminyltransferase activity | GALNTL4,POC1BL,MGAT1A,POMGNT2,UGGT1,GCNT4A,GLT8D1,PIGB,A4GNT,B3GNTL1 |
| transferase activity | PKMA,EPHB4A,RFNG,ZDHHC21,CMPK,UGT5B2,PKM,B4GALNT4,TNIKB,ZDHHC13 |
Interacting Protein
XYLT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XYLT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XYLT1.
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References
- Burlak, C; Bern, M; et al. N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens. XENOTRANSPLANTATION 20:277-291(2013).
- Venkatesan, N; Tsuchiya, K; et al. Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-beta 1-Induced Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 50:583-594(2014).
