XRCC3
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Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 3 -
Overview
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. -
Synonyms
XRCC3;X-ray repair complementing defective repair in Chinese hamster cells 3;DNA repair protein XRCC3;RAD51 like;X-ray repair cross-complementing protein 3;CMM6
Recombinant Proteins
- Chicken
- Mouse
- Zebrafish
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XRCC3-1628C | Recombinant Chicken XRCC3 | Mammalian Cells | Chicken | His |
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| XRCC3-18637M | Recombinant Mouse XRCC3 Protein | Mammalian Cells | Mouse | His |
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| XRCC3-2205Z | Recombinant Zebrafish XRCC3 | Mammalian Cells | Zebrafish | His |
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| XRCC3-30133TH | Recombinant Human XRCC3, T7 -tagged | E.coli | Human | T7 | Full L. |
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| XRCC3-3057H | Recombinant Human XRCC3, T7-tagged | E.coli | Human | T7 | 1-346 a.a. |
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| XRCC3-627H | Recombinant Human XRCC3 Protein, His-tagged | E.coli | Human | His |
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| XRCC3-628H | Recombinant Human XRCC3 Protein, His-tagged | E.coli | Human | His |
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| XRCC3-629H | Recombinant Human XRCC3 Protein, His-tagged | E.coli | Human | His |
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| XRCC3-7094H | Recombinant Human XRCC3, His-tagged | E.coli | Human | His | 1-346aa |
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| XRCC3-256HCL | Recombinant Human XRCC3 293 Cell Lysate | HEK293 | Human | Non |
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| XRCC3-10241M | Recombinant Mouse XRCC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| XRCC3-10241M-B | Recombinant Mouse XRCC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| XRCC3-3772H | Recombinant Human XRCC3 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-316aa |
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| XRCC3-598H | Recombinant Human XRCC3 Protein, His-tagged | E.coli | Human | His | Met1-Phe249 |
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| Xrcc3-599M | Recombinant Mouse Xrcc3 Protein, His-tagged | E.coli | Mouse | His | Met1-His224 |
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Involved Pathway
XRCC3 involved in several pathways and played different roles in them. We selected most pathways XRCC3 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | RAD51B,BLM,RPA4,SYCP3,RAD51C,CDK5R2,TOP3B,SSBP1,RAD51D,RAD52 |
Protein Function
XRCC3 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,contributes_to crossover junction endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC3 itself. We selected most functions XRCC3 had, and list some proteins which have the same functions with XRCC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| recombinase activity | RBPJ,RAD51B,RAD51,RAD51L3,XRCC2,RAD51D,RAD51C,RAD51L1,DMC1 |
| contributes_to four-way junction DNA binding | RAD51C,RAD51L3,RAD51L1,MSH2,RAD51B,MSH6,RAD51D,XRCC2 |
| single-stranded DNA binding | HMGB2,ALYREF,SSBP4,NCL,FBXO18,TREX1,MCM4,RTF1,POLR2G,RAD51L1 |
| ATP binding | ACTG1,ABCB6,DYRK1A,CDC7,ATP2B1A,SMC1B,ACSL4,AKT3,ATP1A1A.2,INSR |
| DNA-dependent ATPase activity | DDX11,CHD8,MSH2,RAD51L1,ERCC2,SMARCA4,IGHMBP2,TOP2A,XRCC2,CDK7 |
| contributes_to crossover junction endodeoxyribonuclease activity | SLX4,RAD51C |
| double-stranded DNA binding | YBX1,IFI16,RBMS1,MCM10,MTERFD2,APTX,PNKP,KIN,GATA1A,DMC1 |
| protein binding | MIEF1,KCNH2,ARPIN,MRPL53,HIST1H4L,HIST1H4C,LGR6,FOXK1,TBC1D19,DCLRE1B |
Interacting Protein
XRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC3.
RAD51C;RAD51;PALB2;BRCA2;SWSAP1;ZSWIM7;SNAI1
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References
- Kajita, M; Okazawa, T; et al. Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 110:351-358(2010).
- Kajita, M; Magari, M; et al. Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 109:407-410(2010).
