XK
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Official Full Name
X-linked Kx blood group (McLeod syndrome) -
Overview
This locus controls the synthesis of the Kell blood group precursor substance (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. -
Synonyms
XK;X-linked Kx blood group (McLeod syndrome);Kell blood group precursor (McLeod phenotype) , XK, Kell blood group complex subunit (McLeod syndrome);membrane transport protein XK;Kx;Kx antigen;X1k;XKR1;Kell complex 37 kDa component;XK related protein 1;XRG1;XK-related protein 1;Kell blood group precursor (McLeod phenotype);XK, Kell blood group complex subunit (McLeod syndrome);MCLDS
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XK-3750H | Recombinant Human XK, GST-tagged | E.coli | Human | GST | 371-444aa | |
| XK-2009Z | Recombinant Zebrafish XK | Mammalian Cells | Zebrafish | His |
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| XK-3280C | Recombinant Chicken XK | Mammalian Cells | Chicken | His |
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| XK-6612R | Recombinant Rat XK Protein | Mammalian Cells | Rat | His |
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| XK-1936HCL | Recombinant Human XK cell lysate | Human | Non |
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| XK-6268R | Recombinant Rat XK Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| XK-6268R-B | Recombinant Rat XK Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
XK involved in several pathways and played different roles in them. We selected most pathways XK participated on our site, such as Class A/1 (Rhodopsin-like receptors),GPCR ligand binding,Peptide ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with XK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | STARD13,TLE3B,NEDD8L,ARHGAP11A,SOUL4,ARHGEF1B,IQGAP3,RCA2.1,ARAP2,TLE3 |
| GPCR ligand binding | CXCR7B,GPR132,GPR65,SETD6,SCT,RLN3A,CCL35.1,NMBA,EDNRB,PPY |
| Signaling by GPCR | PRKCHB,GAL,OPN5,EMR2,RXFP2B,OPN1LW2,RGS17,RGS7,GPR4,RLN2 |
| Peptide ligand-binding receptors | NPB,NPSR1,OXTRL,UTS2,PROKR1A,MLN,QRFP,FPR-RS6,NMBA,PMCH |
| Class A/1 (Rhodopsin-like receptors) | OPN1SW1,CCL19A.2,ANXA1,TRH,EDNRA,MLN,NPFF,ADORA1,OXGR1,GPR77 |
Protein Function
XK has several biochemical functions, for example, protein binding,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XK itself. We selected most functions XK had, and list some proteins which have the same functions with XK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | MIPB,SYPA,AP3D1,ABCC1,RLBP1B,ABCB11,OCA2,SLC15A5,ABCB10,SLC25A38B |
| protein binding | PPM1G,GRIN2B,KHDRBS1,AP1S2,NKX3,RPS7,ACTL6A,ZNF572,MEAF6,SNX10 |
Interacting Protein
XK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XK here. Most of them are supplied by our site. Hope this information will be useful for your research of XK.
CLGN
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References
- Monfort, M; Peyrard, T; et al. A KEL*02(mod) allele responsible for an apparent maternity exclusion. TRANSFUSION CLINIQUE ET BIOLOGIQUE 20:490-495(2013).
- Guarrera, JV; Stone, J; et al. A novel ex-vivo porcine renal xenotransplantation model using a pulsatile machine preservation system. ANNALS OF TRANSPLANTATION 16:80-82(2011).
