WNK2
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Official Full Name
WNK lysine deficient protein kinase 2 -
Overview
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] -
Synonyms
WNK2;WNK lysine deficient protein kinase 2;PRKWNK2;NY-CO-43;SDCCAG43;P/OKcl.13;serine/threonine-protein kinase WNK2;antigen NY-CO-43;protein kinase with no lysine 2;protein kinase lysine-deficient 2;protein kinase, lysine deficient 2;serologically defined colon cancer antigen 43;mitogen-activated protein kinase kinase kinase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WNK2-18561M | Recombinant Mouse WNK2 Protein | Mammalian Cells | Mouse | His |
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| WNK2-10188M | Recombinant Mouse WNK2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| WNK2-10188M-B | Recombinant Mouse WNK2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
WNK2 involved in several pathways and played different roles in them. We selected most pathways WNK2 participated on our site, such as Ion channel transport,Stimuli-sensing channels,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | CLCN2,CLCNKA,CLIC2,SLC17A3,ANO9,CLCN6,TRPC4APB,UNC79,CLCN7,TRPM1 |
| Ion channel transport | CLCN7,TRPC4,ATP6V1G3,TRPM1A,ANO10A,ATP13A1,TRPC4APB,HTR3C,FXYD6,TRDN |
| Transmembrane transport of small molecules | SLC15A3,SLC1A7B,SLC43A2,SLC31A1,ATP11C,PIP,TRPC4APB,TFR1B,SLC39A14,SLC20A1A |
Protein Function
WNK2 has several biochemical functions, for example, ATP binding,kinase activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by WNK2 itself. We selected most functions WNK2 had, and list some proteins which have the same functions with WNK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | SHISA7,SRRD,MAGEA5,GSDMC,CXX1B,UBL5,AP2A2,HAUS4,ZPCX,ARL6IP5 |
| ATP binding | PRKACA,HIPK3B,GM711,GC3,DDX47,OAS3,Adcy4,TTL,FLT3,IDE |
| protein serine/threonine kinase activity | PIK3CA,HIPK4,RPS6KA3,MAPK6,ULK2,PRPF4B,TTBK1,MARK1,MAP2K2A,GM711 |
| nucleotide binding | RBPMS,SMYHC3,NEK5,KALRN,MAP2K4A,LARP6,HNRNPA0B,CKBB,GM4922,ARF6B |
| transferase activity | PTDSS2,PKN1B,PRMT8B,SETD1BA,UBE2D2A,SETD8A,EXT1A,MAP2K4A,ZDHHC18,GPT2L |
| kinase activity | HMGXB3,BMPR1AB,PI4KAA,EPHB2B,MAP3K12,KDRL,MOB1BA,PFKFB2A,FGFR1A,CSNK1G2A |
| protein kinase activity | MAPKAPK2A,BMPR1AA,MAP3K5,AURKA,EIF2AK3,RLN1,SNRKB,MAP2K4,PDGFRA,CDKL3 |
Interacting Protein
WNK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNK2.
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References
- Lai, JG; Tsai, SM; et al. Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling. PLOS ONE 9:-(2014).
- de los Heros, P; Alessi, DR; et al. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. BIOCHEMICAL JOURNAL 458:559-573(2014).
