WFDC1
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Official Full Name
WAP four-disulfide core domain 1 -
Overview
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. -
Synonyms
WFDC1;WAP four-disulfide core domain 1;WAP four-disulfide core domain protein 1;PS20;ps20 growth inhibitor;prostate stromal protein ps20;WAP four-disulfide core domain 1 homolog
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Zebrafish
- Chicken
- Rat
- E.coli
- N-His
- Mammalian Cells
- HEK293
- GST
- His
- T7
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
WFDC1 involved in several pathways and played different roles in them. We selected most pathways WFDC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WFDC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WFDC1 has several biochemical functions, for example, molecular_function,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WFDC1 itself. We selected most functions WFDC1 had, and list some proteins which have the same functions with WFDC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SPINT1A,SERPINF2,ITIH5,SERPINA11,WFIKKN1,WFDC6B,WFDC5,COL6A3,WFDC3,APP |
| molecular_function | BTN2A1,GOLIM4B,HIST1H2BQ,GM581,ARXES2,ARL6IP5A,CRYBB1L3,ASB5B,CCDC15,IFT80 |
Interacting Protein
WFDC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFDC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFDC1.
XRCC2;EZR;FOSL1;RAB40B;ZNF677
Resources
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References
- Ressler, SJ; Dang, TD; et al. WFDC1 Is a Key Modulator of Inflammatory and Wound Repair Responses. AMERICAN JOURNAL OF PATHOLOGY 184:2951-2964(2014).
- Alvarez, RA; Thorborn, G; et al. WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions. RETROVIROLOGY 8:-(2011).
