WDFY3
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Official Full Name
WD repeat and FYVE domain containing 3 -
Overview
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. -
Synonyms
WDFY3;WD repeat and FYVE domain containing 3;WD repeat and FYVE domain-containing protein 3;ALFY;KIAA0993;ZFYVE25;Autophagy linked FYVE protein;MGC16461;autophagy-linked FYVE protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| WDFY3-3704H | Recombinant Human WDFY3, His-tagged | E.coli | Human | His | C-278aa | |
| WDFY3-18445M | Recombinant Mouse WDFY3 Protein | Mammalian Cells | Mouse | His |
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| WDFY3-10117M | Recombinant Mouse WDFY3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| WDFY3-10117M-B | Recombinant Mouse WDFY3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
WDFY3 involved in several pathways and played different roles in them. We selected most pathways WDFY3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WDFY3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
WDFY3 has several biochemical functions, for example, 1-phosphatidylinositol binding,beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDFY3 itself. We selected most functions WDFY3 had, and list some proteins which have the same functions with WDFY3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | GM5077,ZNF395B,CENPT,NEK3,MICAL2,KCND3,CTH1,OVOL1,SDHD,KLF7B |
| 1-phosphatidylinositol binding | SCIN,SNX9,PLEKHA4,SYT1,SCARB1,PICALMB,EEA1,SNX10,PICALM,FRMPD2 |
| protein binding | KCNJ15,BLOC1S2,C2orf88,CYS1,TRPS1,JMJD6,SIK2,MAF,SMURF2,STXBP4 |
| beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity | B4GALT3,B4GALT2,B4GALT7,B4GALT1 |
Interacting Protein
WDFY3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDFY3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDFY3.
MAP1LC3B;GABARAP
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