WARS
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Official Full Name
tryptophanyl-tRNA synthetase -
Overview
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
WARS;tryptophanyl-tRNA synthetase;IFI53;tryptophanyl-tRNA synthetase, cytoplasmic;IFP53;tryptophan tRNA ligase 1;cytoplasmic;Gamma 2;Gamma2;hWRS;IFI 53;IFP 53;Interferon induced protein 53;Interferon-induced protein 53;SYWC_HUMAN;T2-TrpRS;TrpRS;Tryptophan tRNA ligase 1 cytoplasmic;Tryptophan tRNA ligase;Tryptophan--tRNA ligase;Tryptophanyl tRNA synthetase;Tryptophanyl tRNA synthetase cytoplasmic;WARS protein;WRS;OTTHUMP00000246493;OTTHUMP00000246494;OTTHUMP00000246495;OTTHUMP00000246496;OTTHUMP00000246497;OTTHUMP00000246498;tryptophan tRNA ligase 1, cytoplasmic;GAMMA-2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- Yeast
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- His&Myc
- Myc&DDK
Involved Pathway
WARS involved in several pathways and played different roles in them. We selected most pathways WARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with WARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | FARSB,QRSL1,SARS,CARS,YARS2,PARS2,VARS,PET112L,PSTK,GATB |
Protein Function
WARS has several biochemical functions, for example, ATP binding,protein binding,tryptophan-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WARS itself. We selected most functions WARS had, and list some proteins which have the same functions with WARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TAF1,CGA,POLR2L,GLB1,DNAJC28,MIF4GD,GRIFIN,VPS8,TAGLN,KLRC4-KLRK1 |
| tryptophan-tRNA ligase activity | WARS2 |
| ATP binding | PAK1,VRK1,MAPK11,ACTR1B,ITPK1A,ACTR8,CKMT1A,HSPA8,NUBPL,CKB |
Interacting Protein
WARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WARS here. Most of them are supplied by our site. Hope this information will be useful for your research of WARS.
TERF1;DDA1;MDH2;DOC-1R;DCAF13;DNMT3B
Resources
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References
- Sancak, A; Favrot, C; et al. Antibody titres against canine papillomavirus 1 peak around clinical regression in naturally occurring oral papillomatosis. VETERINARY DERMATOLOGY 26:57-+(2015).
- Whitby, T; Schroeder, D; et al. Modifications in Integrin Expression and Extracellular Matrix Composition in Children with Biliary Atresia. KLINISCHE PADIATRIE 227:15-22(2015).
