VEZT
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Official Full Name
vezatin, adherens junctions transmembrane protein -
Overview
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3 UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. -
Synonyms
VEZT;vezatin, adherens junctions transmembrane protein;vezatin;DKFZP761C241
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Xenopus laevis
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Pongo Abelii
- E.coli
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
VEZT involved in several pathways and played different roles in them. We selected most pathways VEZT participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with VEZT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
VEZT has several biochemical functions, for example, myosin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VEZT itself. We selected most functions VEZT had, and list some proteins which have the same functions with VEZT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCL11,CLDN1,LPXN,HDLBP,OTULIN,ZBTB49,DCP1A,TBL1X,COPS4,MS4A12 |
| myosin binding | FXYD1,TRIM32,CALM,NPHS1,KIRREL,ACTC1,ACTA1,RHOA,STX4A,USH2A |
Interacting Protein
VEZT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VEZT here. Most of them are supplied by our site. Hope this information will be useful for your research of VEZT.
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References
- Miao, RZ; Guo, XB; et al. VEZT, a Novel Putative Tumor Suppressor, Suppresses the Growth and Tumorigenicity of Gastric Cancer. PLOS ONE 8:-(2013).
- Bahloul, A; Simmler, MC; et al. Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells. EMBO MOLECULAR MEDICINE 1:125-138(2009).
