VDAC2

  • Official Full Name

    voltage-dependent anion channel 2

  • Overview

    This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.

  • Synonyms

    VDAC2;voltage-dependent anion channel 2;voltage-dependent anion-selective channel protein 2;outer mitochondrial membrane protein porin 2;POR;FLJ23841

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Chicken
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
VDAC2-3658H Recombinant Human VDAC2, GST-tagged E.coli Human GST 1-294aa
VDAC2-18001M Recombinant Mouse VDAC2 Protein Mammalian Cell Mouse His
VDAC2-5151R Recombinant Rhesus monkey VDAC2 Protein, His-tagged Mammalian Cell Rhesus macaque His
VDAC2-6306C Recombinant Chicken VDAC2 Mammalian Cell Chicken His
VDAC2-6511R Recombinant Rat VDAC2 Protein Mammalian Cell Rat His
VDAC2-9988Z Recombinant Zebrafish VDAC2 Mammalian Cell Zebrafish His
VDAC2-418HCL Recombinant Human VDAC2 293 Cell Lysate HEK293 Human Non
VDAC2-10007M Recombinant Mouse VDAC2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
VDAC2-10007M-B Recombinant Mouse VDAC2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
VDAC2-4964R Recombinant Rhesus Macaque VDAC2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
VDAC2-4964R-B Recombinant Rhesus Macaque VDAC2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
VDAC2-6167R Recombinant Rat VDAC2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
VDAC2-6167R-B Recombinant Rat VDAC2 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    VDAC2 involved in several pathways and played different roles in them. We selected most pathways VDAC2 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with VDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway GNAI2,VDAC1,NFATC3,RHOA,RGS2,ATP2A1,INS1,MAP2K1,ATP2B1,NFATC2
    Parkinsons disease PPIF,SLC18A2,ATP5E,ATP5G1,NDUFA8,UQCR11,MT-ND4,UBE2J1,NDUFA6,TH
    Huntingtons disease COX6C,NDUFS3,NDUFS6,COX6B2,EP300,NDUFV1,NDUFB6,POLR2I,DNAH14,UQCR10
    Calcium signaling pathway DRD1,PHKG1A,PRKACAA,GNA15.1,PLCG2,ADORA2A,BDKRB1,SLC8A1B,CHRM2A,TACR1B
    HTLV-I infection SLC2A1,TGFB1,HLA-DRA,GSK3B,TBPL2,WNT7A,POLB,NRP1,RANBP3,HLA-C

    Protein Function

    VDAC2 has several biochemical functions, for example, nucleotide binding,porin activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VDAC2 itself. We selected most functions VDAC2 had, and list some proteins which have the same functions with VDAC2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding WDR77,PTPMT1,GTF2A1,POP1,PTPN14,PRAP1,HSP90AB1,CLSTN2,FAM86C,AP2S1
    nucleotide binding RPS6KB1B,ATP8B1,AKAP17A,NME2A,ABCC12,DNM2A,TRNAU1APB,ABCA9,BRAP,ATP1A3A
    porin activity VDAC1,VDAC3,TOMM40L,AQP9,TOMM40
    voltage-gated anion channel activity VDAC3,GPR89,VDAC1,SLC17A3

    Interacting Protein

    VDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of VDAC2.

    FAM162A;env;env;ACTB;DHRS2;CLN3;SERINC3;BAK1;TRAF6;q81y32_bacan;atoE;Trappc11;15-deoxy-delta(12,14;MTX2;Mtx2;MME;ATF2

    Resources

    References

    • Chang, JS; Chi, SC; et al. GHSC70 Is Involved in the Cellular Entry of Nervous Necrosis Virus. JOURNAL OF VIROLOGY 89:61-70(2015).
    • Petit, FM; Serres, C; et al. Moonlighting proteins in sperm-egg interactions. BIOCHEMICAL SOCIETY TRANSACTIONS 42:1740-1743(2014).

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