VAPA
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Official Full Name
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -
Overview
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. -
Synonyms
VAPA;VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa;VAMP (vesicle associated membrane protein) associated protein A (33kD);vesicle-associated membrane protein-associated protein A;hVAP 33;VAP A;33 kDa Vamp-associated protein;VAMP A;VAMP associated protein A;VAMP-A;VAMP-associated protein A;VAP 33;VAP-33;VAP-A;VAP33;VAPA_HUMAN;Vesicle associated membrane protein associated protein A;OTTHUMP00000162362;OTTHUMP00000162363;hVAP-33
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
VAPA involved in several pathways and played different roles in them. We selected most pathways VAPA participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VAPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | EPB41L1,MYLPFB,MAGI2,PARD6B,MYH11A,MAGI1,CASKA,JAM3B,ACTN2,PTENB |
Protein Function
VAPA has several biochemical functions, for example, FFAT motif binding,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VAPA itself. We selected most functions VAPA had, and list some proteins which have the same functions with VAPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | PHRF1,CHMP1B,YWHAE1,SKIL,TACC1,IKBKG,IRS2,HIST2H4A,ETV6,YWHAQ |
| protein heterodimerization activity | IKBKB,JAM2,HIST1H4H,UBXN6,HIST1H4E,HIST1H2AG,DDX1,HIST1H3H,HIST3H2BB,VEGFB |
| protein binding | TJAP1,C22orf28,PRKAR2AA,MAP4,STAP2,SEPT6,TRIM43,NFE2L3,RAB33B,DYNC1I2 |
| microtubule binding | NDEL1B,SKA1,KIFC1,KIF5A,NDEL1A,SPAG8,KIF4A,KIF13B,LRPPRC,EML2 |
| signal transducer activity | GPR62,GJA1,CBLC,CTNNB2,PLCH1,TAAR10B,TAS2R200.2,ASZ1,TAAR14E,RGRA |
| FFAT motif binding | VAPB,VAPAL |
Interacting Protein
VAPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VAPA here. Most of them are supplied by our site. Hope this information will be useful for your research of VAPA.
p27958-pro_0000037576;p27958-pro_0000037577;q03463-pro_0000278740;YIF1A;q03463-pro_0000278741
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References
- Deidda, I; Galizzi, G; et al. Expression of vesicle-associated membrane-protein-associated protein B cleavage products in peripheral blood leukocytes and cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. EUROPEAN JOURNAL OF NEUROLOGY 21:478-485(2014).
- Vanden Bergh, P; Burr, SE; et al. Antigens of the type-three secretion system of Aeromonas salmonicida subsp salmonicida prevent protective immunity in rainbow trout. VACCINE 31:5256-5261(2013).
