USO1
-
Official Full Name
USO1 vesicle docking protein homolog -
Overview
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, GM130 and giantin in a sequential manner. -
Synonyms
USO1;USO1 vesicle docking protein homolog (yeast);USO1 homolog, vesicle docking protein (yeast);general vesicular transport factor p115;p115;TAP;transcytosis associated protein;VDP;vesicle docking protein;protein USO1 homolog;vesicle-docking pro
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Flag
- His&Fc&Avi
- His&GST
- Myc&DDK
Involved Pathway
USO1 involved in several pathways and played different roles in them. We selected most pathways USO1 participated on our site, such as Arf1 pathway,Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with USO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| COPII (Coat Protein 2) Mediated Vesicle Transport | CNIH3,PPP6C,NSFA,TRAPPC10,TRAPPC9,NSFB,CNIH2,TRAPPC2,TRAPPC2L,AREG |
| Asparagine N-linked glycosylation | MGAT4A,CTSC,ZNF408,PPP6C,MAN1A2,ST3GAL3A,CNIH3,ANKRD28,DAD1,TRAPPC6B |
| M Phase | CDCA5,SKA2,PDS5B,DULLARD,VRK2,PDS5A,CENPK,CTDNEP1B,CENPP,KNTC1 |
| ER to Golgi Anterograde Transport | TRAPPC3,TRAPPC6B,TRAPPC2L,CNIH3,GOLGA2,NAPAB,PPP6R3,PPP6R1,CTAGE5,NSFA |
| Arf1 pathway | ARFIP2,AP2M1,CLTA,AP2A1,CLTB,ARF1 |
| Cell cycle | CCNB2,DYNC1H1,MAD2L1,MCM5,ENSA,WEE2,ERCC6L,CDK11B,SMAD3,SMC2 |
| Golgi Cisternae Pericentriolar Stack Reorganization | BLZF1,GORASP2,GOLGA2,GORASP1 |
| Cell Cycle, Mitotic | TOP2A,LIN9,NEDD1,CENPN,FGFR1OP,DCTN3,HIST4H4,DYRK1A,CENPQ,CKAP5 |
Protein Function
USO1 has several biochemical functions, for example, poly(A) RNA binding,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by USO1 itself. We selected most functions USO1 had, and list some proteins which have the same functions with USO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MED14,DHRS2,ATOX1,RING1,MINK1,THBD,TRIM3,SERPINC1,TPP1,UBOX5 |
| protein transporter activity | COG3,SEC62,KPNA3,IPO9,AP3S1,IPO5,VPS35,KPNA4,RANBP6,ZFYVE16 |
| poly(A) RNA binding | RAVER1,LRRC59,RPS12,RPS20,NKRF,HIST1H4D,CDC42EP4,IFIT2,KIAA1324,METTL16 |
Interacting Protein
USO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of USO1.
PHYKPL;AKAP9;XPO7;DUSP12;7242199;PTP4A3;ARF6;TRAF3;GSTK1;IKBKG;GAK
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