USH1C
-
Official Full Name
Usher syndrome 1C (autosomal recessive, severe) -
Overview
This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
USH1C;Usher syndrome 1C (autosomal recessive, severe);deafness, autosomal recessive 18 , DFNB18;harmonin;AIE 75;NY CO 37;NY CO 38;PDZ 73;PDZ73;antigen NY-CO-38/NY-CO-37;usher syndrome type-1C protein;renal carcinoma antigen NY-REN-3;autoimmune
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Mammalian Cells
- GST
- His
- Non
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| USH1C-3610H | Recombinant Human USH1C, GST-tagged | E.coli | Human | GST | N-term-392aa | |
| USH1C-3847H | Recombinant Human USH1C protein, His-tagged | E.coli | Human | His | Met1-Phe552 | |
| USH1C-29610TH | Recombinant Human USH1C, His-tagged | E.coli | Human | His | 533 amino acids |
|
| USH1C-29611TH | Recombinant Human USH1C, His-tagged | E.coli | Human | His | 1-533 a.a. |
|
| USH1C-3685Z | Recombinant Zebrafish USH1C | Mammalian Cells | Zebrafish | His |
|
|
| USH1C-475H | Recombinant Human Usher Syndrome 1C, His-tagged | E.coli | Human | His |
|
|
| USH1C-1892HCL | Recombinant Human USH1C cell lysate | Human | Non |
|
||
| USH1C-4973H | Recombinant Human USH1C protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-533aa |
|
Involved Pathway
USH1C involved in several pathways and played different roles in them. We selected most pathways USH1C participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USH1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
USH1C has several biochemical functions, for example, actin filament binding,myosin tail binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USH1C itself. We selected most functions USH1C had, and list some proteins which have the same functions with USH1C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| spectrin binding | UNC13A,GBP1,MYO10,DCTN2,ADD2,SPTAN1,USH1G,STX4A,EPB41,PTPRN |
| actin filament binding | TRIOBPB,PLDN,ACTN2B,SHROOM2,SHROOM4,TULP1,LIMA1,PPP1R9A,CORO1A,ACTN1 |
| protein binding | HSPA4,TXNDC9,PKD2L1,TMEM242,DLAT,VPS33A,RIBC1,MED27,CFLAR,cgr2b |
Interacting Protein
USH1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USH1C here. Most of them are supplied by our site. Hope this information will be useful for your research of USH1C.
RAC1;MIPOL1;CTNNAL1;USHBP1;QKI;pi3p;USH1G;CDHR2
Resources
Related Services
Related Products
References
- Lampasona, V; Passerini, L; et al. Autoantibodies to Harmonin and Villin Are Diagnostic Markers in Children with IPEX Syndrome. PLOS ONE 8:-(2013).
- Zhao, HY; Avenarius, MR; et al. Improved Biolistic Transfection of Hair Cells. PLOS ONE 7:-(2012).
