UQCRQ
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Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -
Overview
This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. -
Synonyms
UQCRQ;ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa;cytochrome b-c1 complex subunit 8;complex III subunit 8;QCR8;QP C;ubiquinol cytochrome c reductase;complex III subunit VII;UQCR7;complex III subunit VIII;low molecular mass
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi
- Fc
- GST
Involved Pathway
UQCRQ involved in several pathways and played different roles in them. We selected most pathways UQCRQ participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with UQCRQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | SDHB,PPP3CA,CALML5,CASP7,CHP,FADD,GRIN2A,PLCB4,COX4I2,LPL |
| Metabolic pathways | NT5C,HGD,NDUFA5,NME2,MTHFD2,NDUFA2,PIK3C2B,PLA2G3,PNLIPRP3,COX6A1 |
| Huntingtons disease | PPARGC1A,NDUFC2,Casp3,NDUFA12,NDUFB9,SOD2,SOD1,GRIN2B,NDUFC2-KCTD14,NDUFB6 |
| Oxidative phosphorylation | COX7A2A,NDUFB2,ATP6V0D2,ATP6V1G1,NDUFS8,ATP6V0C,NDUFS3,ATP6V1E1B,PPA1,ATPV0E2 |
| Non-alcoholic fatty liver disease (NAFLD) | FASLG,ATF4,BID,NDUFB7,COX5A,GSK3B,LEP,PIK3R2,NDUFB1,PRKAA2 |
| Parkinsons disease | NDUFA1,UQCRC1,NDUFA5,NDUFA11,SLC25A31,NDUFS4,GNAI2,SEPT5,NDUFA13,PRKACB |
| Cardiac muscle contraction | ATP1B1,COX5B2,ATP1A3,ATP2A2,UQCRH,ATP1B1A,MYL3,ATP1A1A.1,CACNG7A,CACNA2D1A |
Protein Function
UQCRQ has several biochemical functions, for example, ubiquinol-cytochrome-c reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UQCRQ itself. We selected most functions UQCRQ had, and list some proteins which have the same functions with UQCRQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquinol-cytochrome-c reductase activity | UQCR11,UQCRFS1,UQCRC1,UQCR10,UQCRH |
Interacting Protein
UQCRQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UQCRQ here. Most of them are supplied by our site. Hope this information will be useful for your research of UQCRQ.
UQCRC1;OPTN;ERCC8;GRINL1A;Dctn1;XRCC3;PML;RAB7A;HNRNPA1L2;CDC73;NLRP3;HAUS2;TMEM248;GOLT1B
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References
- Perry, MC; Dufour, CR; et al. Estrogen-Related Receptor-alpha Coordinates Transcriptional Programs Essential for Exercise Tolerance and Muscle Fitness. MOLECULAR ENDOCRINOLOGY 28:2060-2071(2014).
- Mazzio, EA; Boukli, N; et al. Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells. CANCER SCIENCE 103:422-432(2012).
