UPB1
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Official Full Name
ureidopropionase, beta -
Overview
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. -
Synonyms
UPB1;ureidopropionase, beta;beta-ureidopropionase;BUP1;BUP-1;beta-alanine synthase;n-carbamoyl-beta-alanine amidohydrolase
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UPB1-10017Z | Recombinant Zebrafish UPB1 | Mammalian Cells | Zebrafish | His |
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| UPB1-113H | Recombinant Human UPB1 Protein, His-tagged | E.coli | Human | His |
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| UPB1-49H | Recombinant Human UPB1, His-tagged | E.coli | Human | His | 1-384 a.a. |
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| UPB1-6455R | Recombinant Rat UPB1 Protein | Mammalian Cells | Rat | His |
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| Upb1-7919M | Recombinant Mouse Upb1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Leu154~Gly393 |
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| UPB1-495HCL | Recombinant Human UPB1 293 Cell Lysate | HEK293 | Human | Non |
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| Upb1-225M | Recombinant Mouse Upb1 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| UPB1-5906H | Recombinant Human UPB1 Protein (Trp121-Glu384), N-His tagged | E.coli | Human | His | Trp121-Glu384 |
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| UPB1-6111R | Recombinant Rat UPB1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| UPB1-6111R-B | Recombinant Rat UPB1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| UPB1-967H | Recombinant Human UPB1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
UPB1 involved in several pathways and played different roles in them. We selected most pathways UPB1 participated on our site, such as Pyrimidine metabolism,beta-Alanine metabolism,Pantothenate and CoA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | Nat3,CDA,UGT1A9,TK2,CES1D,PNAT10,DPYD,ITPA,UCK2,UGT1A3 |
| beta-Alanine metabolism | ALDH9A1B,ALDH2,CARNS1,ALDH9A1,ALDH3A2,ALDH1A3,HIBCH,ALDH7A1,ALDH1B1,ALDH3A2A |
| Pyrimidine metabolism | ENTPD4,NT5C1A,POLR2GL,DPYDA.1,UCK2B,POLR2B,POLR2J2,RRM1,ENTPD5,POLR2G |
| Pantothenate and CoA biosynthesis | PANK3,PANK4,DPYS,PANK1,VNN1,PPCS,ENPP1,ENPP3,AASDHPPT,PPCDC |
| Metabolic pathways | Akr1b3,MTMR1B,IDH3B,NSDHL,NT5C1A,DHCR7,ALOX15,ALG5,PLA2G12B,SPAM1 |
Protein Function
UPB1 has several biochemical functions, for example, beta-ureidopropionase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UPB1 itself. We selected most functions UPB1 had, and list some proteins which have the same functions with UPB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ACMSD,MYLIPA,LEPREL1,STK25,CYP2K18,PPTC7,CYBB,DPH3,BRIP1,CYP4F14 |
Interacting Protein
UPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UPB1.
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References
- Lam, CW; Law, CY; et al. NMR-based urinalysis for rapid diagnosis of beta-ureidopropionase deficiency in a patient with Dravet syndrome. CLINICA CHIMICA ACTA 440:201-204(2015).
- Shu, JB; Lv, XQ; et al. Genetic analysis of the UPB1 gene in two new Chinese families with beta-ureidopropionase deficiency and the carrier frequency of the mutation c. 977G > A in Northern China. CHILDS NERVOUS SYSTEM 30:2109-2114(2014).
