UNC13B

  • Official Full Name

    unc-13 homolog B (C. elegans)
  • Overview

    This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
  • Synonyms

    UNC13B;unc-13 homolog B (C. elegans);unc 13 like (C. elegans) , UNC13;protein unc-13 homolog B;hmunc13;Unc13h2;MGC133279;MGC133280;munc13;Munc13-2;UN13B_HUMAN;UNC13;homolog of rat Munc13 (diacylglycerol-binding)

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UNC13B-3596H Recombinant Human UNC13B, GST-tagged E.coli Human GST 1-330aa
UNC13B-17841M Recombinant Mouse UNC13B Protein Mammalian Cells Mouse His
UNC13B-6445R Recombinant Rat UNC13B Protein Mammalian Cells Rat His
UNC13B-6101R Recombinant Rat UNC13B Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
UNC13B-6101R-B Recombinant Rat UNC13B Protein Pre-coupled Magnetic Beads HEK293 Rat
UNC13B-9910M Recombinant Mouse UNC13B Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
UNC13B-9910M-B Recombinant Mouse UNC13B Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    UNC13B involved in several pathways and played different roles in them. We selected most pathways UNC13B participated on our site, such as Acetylcholine Neurotransmitter Release Cycle,Dopamine Neurotransmitter Release Cycle,Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNC13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neurotransmitter Release Cycle CPLX1,RERG,ARL6IP5A,SYN2,SLC1A2A,SLC18A3A,LIN7B,PPFIA1,SLC1A2B,PPFIA2
    Effects of Botulinum toxin CHRNA1,RAB3GAP2,CCDC167
    Neuronal System KCNA6,KCNN3,PANX1A,KCNJ1A.6,Apba1,KCNAB1A,LIN7C,KCNA4,KCNAB1,KCNV2
    Norepinephrine Neurotransmitter Release Cycle STXBP1A,PPFIA2,SYT1A,SNAP25A,RERG,PPFIA4,CPLX1,PPFIA1,SNAP25B,RAB3AB
    Dopamine Neurotransmitter Release Cycle PPFIA4,Apba1,PPFIA2,CPLX1,SYN3,SYN2,PPFIA1,LIN7B,LIN7C,RERG
    Glutamate Neurotransmitter Release Cycle SNAP25A,SLC1A7B,ARL6IP5,SNAP25B,SYT1A,SLC1A2A,SLC1A3B,SLC1A3A,PPFIA4,SLC1A2B
    Monoamine Transport SYN1,HRH3,TGFB1I1,DBH,FBXO32,SCAMP2,TPH2
    Acetylcholine Neurotransmitter Release Cycle PPFIA2,SLC18A3A,PPFIA1,SNAP25B,RAB3AB,CHAT,STXBP1A,BZRAP1,PPFIA4,CPLX2L

    Protein Function

    UNC13B has several biochemical functions, for example, diacylglycerol binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UNC13B itself. We selected most functions UNC13B had, and list some proteins which have the same functions with UNC13B. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ZNF544,ZNF221,ZNF625,ZFP131,ASPHD2,ADSSL,ITGAX,RHEB,GNAT3,FTR67
    diacylglycerol binding UNC13A,RASGRP1,RASGRP4,CDIPT,UNC13C,TRPC2,RASGRP2,RASGRP3
    receptor activity PVRL4,VAC14,Pla2r1,VMN1R43,EXTL3,SELS,GRIA3A,KLRB1F,RTN4RL2,IGF2R
    signal transducer activity V1RA8,OLFR481,OLFR15,GPR89,TAAR11,GPR161,TAAR12C,TACR1A,TMED4,VMN1R52
    protein binding MYCBP2,SPG20,LPAL2,KCND2,TOM1,G0S2,ERCC3,TCOF1,LCMT2,ANGPT2

    Interacting Protein

    UNC13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNC13B here. Most of them are supplied by our site. Hope this information will be useful for your research of UNC13B.

    hslO;TOE1

    Resources

    References

    • Kabachinski, G; Yamaga, M; et al. CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis. MOLECULAR BIOLOGY OF THE CELL 25:508-521(2014).
    • Lauterbach, EC; et al. Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 38:107-115(2012).

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