umuD
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Official Full Name
DNA polymerase V, subunit D -
Overview
The products of umuD, umuC, and recA genes (SOS genes) are required for mutagenesis induced by radiation or chemical agents. Transcription of these SOS genes is repressed by a repressor, LexA protein in uninduced cells. Exposure of cells to DNA-damaging agents activates RecA protein to promote proteolytic cleavage of LexA protein. Inactivation of LexA protein by the cleavage consequently derepresses the SOS genes, umuD, C and recA. UmuD protein is then auto-cleaved, which is promoted by RecA protein ssDNA in a ATP-dependent manner. The processed UmuD protein is the active form for mutagenesis and the UmuD-UmuC complex functions as an error-prone translesion DNA polymerase. The molecular weight of the intact UmuD is 17kD and the proteolytically processed active form is 14kD. -
Synonyms
umuD;DNA polymerase V, subunit D;ECK1171;JW1172;NP_415701.1;SOS mutagenesis;error-prone repair;processed to UmuD';forms complex with UmuC;Bacteria;Proteobacteria;Gammaproteobacteria;Enterobacteriales;Enterobacteriaceae;Escherichia;E. coli;Escherichia coli;Bacillus coli
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Involved Pathway
umuD involved in several pathways and played different roles in them. We selected most pathways umuD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with umuD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
umuD has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by umuD itself. We selected most functions umuD had, and list some proteins which have the same functions with umuD. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
umuD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with umuD here. Most of them are supplied by our site. Hope this information will be useful for your research of umuD.
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