UGT1A5
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A5 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. -
Synonyms
UGT1A5;UDP glucuronosyltransferase 1 family, polypeptide A5;UDP glycosyltransferase 1 family, polypeptide A5;UDP-glucuronosyltransferase 1-5;UGT1E;Ugt1;B5;UD15_HUMAN;UDP glucuronosyltransferase 1 family polypeptide A5s;UDP glycosyltransferase 1 family polypeptide A5;UDP-glucuronosyltransferase 1-E;UDP-glucuronosyltransferase 1A5;UDPGT 1-5;UDPGT;UGT-1E;UGT1*5;UGT1-05;UGT1.5;Ugt1a6;UDP-glucuronosyltransferase 1 family polypeptide A5s
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A5-7720Z | Recombinant Zebrafish UGT1A5 | Mammalian Cell | Zebrafish | His |
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| RFL20958HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1-5(Ugt1A5) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (29-534) |
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| RFL2401RF | Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-5(Ugt1) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (26-531) |
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Involved Pathway
UGT1A5 involved in several pathways and played different roles in them. We selected most pathways UGT1A5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
UGT1A5 has several biochemical functions, for example, glucuronosyltransferase activity,hydrolase activity,transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A5 itself. We selected most functions UGT1A5 had, and list some proteins which have the same functions with UGT1A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity | C1rb,DDHD2,MMP13A,PSD,RTEL1,PTPN2B,ABHD2B,STAMBPA,BAT1,CDC14AB |
| transferase activity | PHKG1A,MAP3K4,STK38A,AGPAT9L,MGST1.1,UGT5B1,ELOVL4B,CDK14,MAPK14A,CHATB |
| glucuronosyltransferase activity | GYLTL1B,UGT1B7,UGT1B3,UGT1B4,UGT5A2,UGT1A6B,UGT3A1,UGT1A2,CSGALNACT1,UGT5A1 |
| transferase activity, transferring glycosyl groups | UGT5A3,FUT8A,GCNT4A,GXYLT1B,GBGT1,LARGE,UGGT1,PYGMA,PYGMB,FT1 |
| transferase activity, transferring hexosyl groups | ALG6,UGT1B7,UGT5B2,UGT5G2,UGT5A4,UGT5D1,UGT5G1,GBGT1,GBGT1L1,PIGM |
Interacting Protein
UGT1A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A5.
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References
- Wang, M; Sun, DF; et al. Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer. PLOS ONE 8:-(2013).
- Heydel, JM; Garnier, P; et al. Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 37:233-240(2012).
