UFL1
-
Official Full Name
UFM1-specific ligase 1 -
Synonyms
UFL1;UFM1-specific ligase 1;KIAA0776;E3 UFM1-protein ligase 1;Maxer;NLBP;novel LZAP binding protein;RCAD;Regulator of CDK5RAP3 and DDRGK1;LZAP-binding protein;novel LZAP-binding protein;RP3-393D12.1
Recombinant Proteins
- Cynomolgus
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
Involved Pathway
UFL1 involved in several pathways and played different roles in them. We selected most pathways UFL1 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UFL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CD300C,LILRA1,CLTC,KLC3,CD200,CD300LH,KIF11,ERAP1,CD200R1,ACTR1B |
| Immune System | CLEC6A,LILRB3,IFI27,CD180,KIF2C,RNF135,PPAPDC1B,IRAK3,SEC23A,CASP2 |
| presentation | KLHL20,WWP1,FBXO27,LTN1,SPSB2,LRSAM1,RNF4,RNF220,CTSS,RNF6 |
| Proteasome degradation | FBXO17,HUWE1,FBXO44,RNF111,RNF182,UBE2V2,ATG7,ASB4,RNF34,ASB18 |
| Antigen processing: Ubiquitination & | FBXO17,FBXO44,ASB17,VPRBP,SH3RF1,RNF6,LRRC41,UBE2J2,UBR1,TPP2 |
| Class I MHC mediated antigen processing & | SPSB1,UBE2L6,ASB13,FBXO44,ASB7,RBCK1,TRIM50,ARIH2,SPSB2,UBA5 |
Protein Function
UFL1 has several biochemical functions, for example, UFM1 transferase activity,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UFL1 itself. We selected most functions UFL1 had, and list some proteins which have the same functions with UFL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPCS1,LRRC4B,IST1,LAMTOR2,RPL11,ARVCF,BOP1,PTH2R,MARCH5,Tnfrsf23 |
| UFM1 transferase activity | UFC1 |
| ligase activity | RTCD1,CBLC,UBE2D1A,LTN1,CCNB1IP1,TRAF3,PARK2,HACE1,RNF4,TRIM11 |
Interacting Protein
UFL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UFL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UFL1.
PTP4A3;CASP4;CDK5RAP3;GSTK1;PHLDA3;UBE2D1;UBE2E1;UBE2D3;UBE2D2;rpoB;UBE2E3;UBE2W;UBE2D4;ssrna_ug;P
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References
- Tatsumi, K; Sou, YS; et al. A Novel Type of E3 Ligase for the Ufm1 Conjugation System. JOURNAL OF BIOLOGICAL CHEMISTRY 285:5417-5427(2010).
- Zhang, YH; Zhang, MS; et al. Transcriptional Regulation of the Ufm1 Conjugation System in Response to Disturbance of the Endoplasmic Reticulum Homeostasis and Inhibition of Vesicle Trafficking. PLOS ONE 7:-(2012).
