UCP3
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Official Full Name
uncoupling protein 3 (mitochondrial, proton carrier) -
Overview
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This genes protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008] -
Synonyms
UCP3;uncoupling protein 3 (mitochondrial, proton carrier);SLC25A9;mitochondrial uncoupling protein 3;solute carrier family 25 member 9
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Chicken
- Mus musculus
- Dog
- Sus scrofa (Pig)
- Bovine
- Mouse
- Mammalian Cells
- E.coli
- Human
- Rat
- HEK293
- His
- Non
- Avi
- Fc
Involved Pathway
UCP3 involved in several pathways and played different roles in them. We selected most pathways UCP3 participated on our site, such as Diurnally regulated genes with circadian orthologs,Electron Transport Chain,Energy Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | COQ7,PNP5B,CYP3C1,SURF1,OSBP,PDK2B,FABP11A,ISCUB,UGT1B7,DPYD |
| Electron Transport Chain | ATP5H,COX6A1,SURF1,COX7C,SCO1,COX5B,SLC25A14,NDUFS7,COX15,COX4I1 |
| The fatty acid cycling model | SLC25A27,SLC25A14,UCP2 |
| Mitochondrial Uncoupling Proteins | UCP2,SLC25A27,SLC25A14 |
| Energy Metabolism | TFB2M,GABPA,TFB1M,MEF2B,PPARGC1B,MYBBP1A,ESRRA,UCP2 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ETFDH,SLC25A27,C20orf7,NDUFAF4,ATP5S,NDUFAF5,NDUFAF7,ATP5L,LRPPRC,FAM36A |
| Diurnally regulated genes with circadian orthologs | KLF9,ITM2B,RBPMS,CRY1,PURA,QK,EIF4G2,AZIN1,NR1D2,G0S2 |
| The citric acid (TCA) cycle and respiratory electron transport | MPC1,D2HGDH,SURF1,SCO1,FAM36A,TACO1,ETFDH,NDUFAF7,UCP2,PDP1 |
Protein Function
UCP3 has several biochemical functions, for example, oxidative phosphorylation uncoupler activity,protein binding,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCP3 itself. We selected most functions UCP3 had, and list some proteins which have the same functions with UCP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transporter activity | APODA.1,SLC12A10.1,MFSD10,ABCG2,ASNA1,SLC12A5B,ABCA4,ABCC9,HIATL2,Abca2 |
| protein binding | MAP2K7,TMED10,NRBP1,SND1,RNF144B,MOAP1,RNF220,MTIF3,TUBGCP4,PLUNC |
| oxidative phosphorylation uncoupler activity | UCP1 |
Interacting Protein
UCP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCP3.
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References
- Xu, HL; Hertzel, AV; et al. Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2. MOLECULAR AND CELLULAR BIOLOGY 35:1055-1065(2015).
- Frisard, MI; Wu, Y; et al. Low Levels of Lipopolysaccharide Modulate Mitochondrial Oxygen Consumption in Skeletal Muscle. METABOLISM-CLINICAL AND EXPERIMENTAL 64:416-427(2015).
