UCN
-
Official Full Name
urocortin -
Overview
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to;the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2;receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name;similarity, the product of this gene has no sequence similarity to urotensin II. -
Synonyms
UCN;urocortin;UI;UROC;UCN1_HUMAN;Urocortin precursor;Urotensin I;OTTHUMP00000122583;urocortin, preproprotein
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- GST&His
- Avi&Fc&His
Involved Pathway
UCN involved in several pathways and played different roles in them. We selected most pathways UCN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
UCN has several biochemical functions, for example, corticotropin-releasing hormone receptor 1 binding,corticotropin-releasing hormone receptor 2 binding,histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCN itself. We selected most functions UCN had, and list some proteins which have the same functions with UCN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone deacetylase inhibitor activity | SKI |
| corticotropin-releasing hormone receptor 2 binding | CRH,UCN2,UCN3L,UCN3 |
| neuropeptide hormone activity | NPFF,POMCA,AVP,CCK,PENK,NPPA,GAL,NTS,TRH,QRFP |
| protein binding | GSDMA2,LMX1B,TERF2,SOCS2,SMYD1,DDX20,TNFAIP8,IL1R2,PPARD,GLYCTK |
| corticotropin-releasing hormone receptor 1 binding | GNAO1B,GNAO1A,GNAS,GNAO1,CRH |
Interacting Protein
UCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCN here. Most of them are supplied by our site. Hope this information will be useful for your research of UCN.
Resources
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References
- Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
- Squillacioti, C; De Luca, A; et al. Presence and Distribution of Urocortin and Corticotrophin-Releasing Hormone Receptors in the Bovine Thyroid Gland. ANATOMIA HISTOLOGIA EMBRYOLOGIA 43:429-434(2014).
