U2AF1
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Official Full Name
U2 small nuclear RNA auxiliary factor 1 -
Overview
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
U2AF1;U2 small nuclear RNA auxiliary factor 1;U2(RNU2) small nuclear RNA auxiliary factor 1 , U2(RNU2) small nuclear RNA auxiliary factor binding protein , U2AFBP;splicing factor U2AF 35 kDa subunit;RN;RNU2AF1;U2AF35;splicing factor U2AF 35kDa sub
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| U2AF1-581H | Recombinant Human U2AF1 protein, GST-tagged | E.coli | Human | GST | 26-240 aa | |
| U2AF1-580H | Recombinant Human U2 small nuclear RNA auxiliary factor 1, His-tagged | E.coli | Human | His | 1-240 a.a. |
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| U2AF1-6223C | Recombinant Chicken U2AF1 | Mammalian Cells | Chicken | His |
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| U2AF1-9571Z | Recombinant Zebrafish U2AF1 | Mammalian Cells | Zebrafish | His |
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| U2AF1-609HCL | Recombinant Human U2AF1 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
U2AF1 involved in several pathways and played different roles in them. We selected most pathways U2AF1 participated on our site, such as Spliceosome,Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | CDC40,U2AF1L4,SRSF10,RBM17,PRPF40A,SF3B14,ZMAT2,SF3B3,THOC2,PRPF6 |
| Shigellosis | UBE2D2,MAPK11,VCL,PFN2,MAPK9,ELMO2,CTTN,MAD2L2,SRC,NFKBIA |
Protein Function
U2AF1 has several biochemical functions, for example, metal ion binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF1 itself. We selected most functions U2AF1 had, and list some proteins which have the same functions with U2AF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | KLF2,XIRP2,UQCRC2B,VDRA,SP3,PLAG1,KLF7A,ITGB1,SIRT1,ZNF285A |
| protein binding | EPS8L1,RFFL,PEPD,TCF7L2,SMU1,USP42,ZNF707,GHRL,RAP1GAP,RSPH3 |
| nucleotide binding | IMPDH2,RRP7A,SEPT9A,GRSF1,APOA1BP,NADKD1,SRSF11,ABCA4A,NLRP9C,ATP13A3 |
| poly(A) RNA binding | DHX38,NUFIP2,RPS24,NSUN2,GNL2,RALYL,CRKL,IFI16,CNOT1,IGF2BP2 |
Interacting Protein
U2AF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF1.
U2AF2;SRPK2;CIR1
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