TYW1
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Official Full Name
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -
Overview
Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006). -
Synonyms
TYW1;tRNA-yW synthesizing protein 1 homolog (S. cerevisiae);radical S adenosyl methionine and flavodoxin domains 1 , RSAFD1;tRNA wybutosine-synthesizing protein 1 homolog;FLJ10900;MGC23001;MGC60291;tRNA yW synthesizing protein 1 homolog A (S. cerevisiae);TYW1A;YPL207W;GC23001;Radical S-adenosyl methionine and flavodoxin domain-containing protein 1;RSAFD1;tRNA-yW-synthesizing protein;TYW1_HUMAN;OTTHUMP00000160137;tRNA-yW synthesizing protein 1 homolog A;radical S-adenosyl methionine and flavodoxin domains 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TYW1-17678M | Recombinant Mouse TYW1 Protein | Mammalian Cells | Mouse | His |
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| TYW1-4615Z | Recombinant Zebrafish TYW1 | Mammalian Cells | Zebrafish | His |
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| TYW1-612HCL | Recombinant Human TYW1 293 Cell Lysate | HEK293 | Human | Non |
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| TYW1-9803M | Recombinant Mouse TYW1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| TYW1-9803M-B | Recombinant Mouse TYW1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TYW1 involved in several pathways and played different roles in them. We selected most pathways TYW1 participated on our site, such as 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis,Gene Expression,Synthesis of wybutosine at G37 of tRNA(Phe), which may be useful for your reference. Also, other proteins which involved in the same pathway with TYW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis | TYW3 |
| Synthesis of wybutosine at G37 of tRNA(Phe) | TYW5,LCMT2,TRMT5,TRMT12,TYW3 |
| tRNA processing | QTRT1,TRMT6,CDKAL1,FAM98B,ALKBH8,METTL1,TYW5,LCMT2,TRMT12,TRMT61A |
| Gene Expression | COBRA1,ZNF143A,NUDT21,ZNF317,DPY19L2,POLR3G,EIF1AX,LSM6,QTRT1,ZNF230 |
| tRNA modification in the nucleus and cytosol | ADAT2,ALKBH8,TPRKB,TRMT112,LCMT2,TYW3,TRMT12,QTRTD1,TRMT61A,THG1L |
| wybutosine biosynthesis | LCMT2,TYW3 |
Protein Function
TYW1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,FMN binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYW1 itself. We selected most functions TYW1 had, and list some proteins which have the same functions with TYW1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | NFU1,IRGM1,CYP2K16,ALOX12E,CYP51A1,CYP46A1.2,CYP2A12,PPEF1,CYP2A13,CYP2AA9 |
| lyase activity | IRG1L,GC3,MVDA,TSEN2,PTGESL,ADCY1B,AGXT2L2,CAR13,THA1,PTGES2 |
| 4 iron, 4 sulfur cluster binding | MOCS1,NTHL1,RTEL1,NFU1,POLD1,NDUFS7,EXO5,POLA1,NDUFS2,ACO1 |
| FMN binding | CREG2,CREG1,NOS2,HAO2,NOS2B,NOS1,NOS2A,POR,PNPO,NDOR1 |
Interacting Protein
TYW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYW1.
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References
- Molle, T; Kathirvelu, V; et al. Radical-SAM enzymes with two FeS clusters, RimO and TYW1: Using spectroscopy to assign the interactions and function of each cluster. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19:S837-S838(2014).
- Young, AP; Bandarian, V; et al. Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. CURRENT OPINION IN CHEMICAL BIOLOGY 17:613-618(2013).
