TUT1
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Official Full Name
terminal uridylyl transferase 1, U6 snRNA-specific -
Overview
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3 end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation. -
Synonyms
TUT1;terminal uridylyl transferase 1, U6 snRNA-specific;RBM21, RNA binding motif protein 21;speckle targeted PIP5K1A-regulated poly(A) polymerase;FLJ21850;FLJ22267;FLJ22347;PAPD2;RNA uridylyltransferase;TUTase;U6 TUTase;alpha regulated poly(A) polymerase;nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I;nuclear speckle targeted PIPK1A regulated poly(A) polymerase;PAP associated domain containing 2;poly(A) polymerase associated domain containing 2;RBM21;RNA binding motif protein 21;STARPAP;terminal uridylyl transferase 1, U6 snRNA specific;U6 snRNA specific terminal uridylyltransferase 1;star-PAP;U6-TUTase;RNA-binding protein 21;RNA-binding motif protein 21;PAP-associated domain-containing 2;U6 snRNA-specific terminal uridylyltransferase 1;nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase;nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase
Recombinant Proteins
- Mouse
- Zebrafish
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TUT1-17641M | Recombinant Mouse TUT1 Protein | Mammalian Cells | Mouse | His |
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| TUT1-3294Z | Recombinant Zebrafish TUT1 | Mammalian Cells | Zebrafish | His |
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| TUT1-6368R | Recombinant Rat TUT1 Protein | Mammalian Cells | Rat | His |
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| TUT1-634HCL | Recombinant Human TUT1 293 Cell Lysate | HEK293 | Human | Non |
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| TUT1-6024R | Recombinant Rat TUT1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TUT1-6024R-B | Recombinant Rat TUT1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Tut1-6738M | Recombinant Mouse Tut1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| TUT1-9776M | Recombinant Mouse TUT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TUT1-9776M-B | Recombinant Mouse TUT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TUT1 involved in several pathways and played different roles in them. We selected most pathways TUT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TUT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
TUT1 has several biochemical functions, for example, ATP binding,RNA binding,RNA uridylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TUT1 itself. We selected most functions TUT1 had, and list some proteins which have the same functions with TUT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPSB1,HSPA14,DDC,RMND5A,MMP20,C10orf137,CAMTA2,PIK3CA,FADD,PPIL2 |
| ATP binding | CSNK1G3,DNAH14,MYO6B,DDX18,MYLK3,ITGB1BP3,NME4,DDX55,TARSL2,PSKH1 |
| metal ion binding | STK24,LATS2,ZMIZ2,POLB,OBSCN,ZFP131,REV3L,NEK8,ZNF383,TRIM41 |
| RNA uridylyltransferase activity | ZCCHC11,ZCCHC6 |
| RNA binding | RPS7,PTBP2B,CPEB1B,MIF4GDA,SRBD1,MTHFSD,EIF5A,PATL2,RPUSD1,NOVA1 |
| enzyme binding | UGT1A2,RCOR3,HDAC6,IQCB1,MST1R,NPM2,EGFR,CYP2C8,ZNHIT6,STUB1 |
| mRNA 3-UTR binding | YBX2,ELAVL1,SERBP1,IGF2BP2,RBM38,RBM4,ZNF385A,PARN,RIMS2,CSDA |
| polynucleotide adenylyltransferase activity | PAPOLA,PAPOLG,PAPD7,PAPD4,PAPOLB,MTPAP |
Interacting Protein
TUT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TUT1.
PRPF4;CPSF1;USP4;SART3;CDC37;USP15;hrpA;CPSF4;CSTF2;YWHAZ;Prpf3;Sart3;CPSF2;CPSF3
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References
- Najjar, A; Abdullah, N; et al. Removal of Phorbol Esters Present in Jatropha curcas Kernel by Fungal Isolates. INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY 16:871-878(2014).
- Zhu, DQ; Lou, YF; et al. Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. TUMOR BIOLOGY 35:11829-11835(2014).
