TTRAP
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Official Full Name
TDP2 tyrosyl-DNA phosphodiesterase 2 -
Overview
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. -
Synonyms
EAP2;AD022;TTRAP;MGC9099;dJ30M3.3;MGC111021;RP1-30M3.3;tyrosyl-DNA phosphodiesterase 2;EAPII;OTTHUMP00000016091;OTTHUMP00000016092;ETS1-associated protein 2;ETS1-associated protein II;tyr-DNA phosphodiesterase 2;5'-Tyr-DNA phosphodiesterase;5'-tyrosyl-DNA phosphodiesterase;TRAF and TNF receptor associated protein;TRAF and TNF receptor-associated protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TTRAP-3483H | Recombinant Human TTRAP, GST-tagged | E.coli | Human | GST | 1-362aa |
Involved Pathway
TTRAP involved in several pathways and played different roles in them. We selected most pathways TTRAP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TTRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
TTRAP has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TTRAP itself. We selected most functions TTRAP had, and list some proteins which have the same functions with TTRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
TTRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TTRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of TTRAP.
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References
- Pommier, Y; Huang, SYN; et al. Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2). DNA REPAIR 19:114-129(2014).
- Lee, Y; Elvitigala, DAS; et al. Structural and functional characterization of a novel molluskan ortholog of TRAF and TNF receptor-associated protein from disk abalone (Haliotis discus discus). FISH & SHELLFISH IMMUNOLOGY 40:32-39(2014).
