TSNAX
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Official Full Name
translin-associated factor X -
Overview
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. -
Synonyms
TSNAX;translin-associated factor X;translin-associated protein X;TRAX;translin-like protein
Recombinant Proteins
- Human
- Cynomolgus
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TSNAX involved in several pathways and played different roles in them. We selected most pathways TSNAX participated on our site, such as Gene Expression,Gene Silencing by RNA,Small interfering RNA (siRNA) biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSNAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Small interfering RNA (siRNA) biogenesis | TSN,TARBP2 |
| Gene Silencing by RNA | EIF2C3,MYBL1,HENMT1,DDX4,ASZ1,TDRD1,IPO8,TARBP2,FKBP6,AGO3B |
| Gene Expression | SKI,POLR3F,ZNF563,ALKBH8,ZNF738,COX8A,ZNF498,ZNF461,ZKSCAN3,SKILB |
Protein Function
TSNAX has several biochemical functions, for example, DNA binding,endoribonuclease activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSNAX itself. We selected most functions TSNAX had, and list some proteins which have the same functions with TSNAX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | KIAA0368,CD72,CNOT4,NOSIP,TECPR2,LRRC4,ZNF3,CBX8,RBM42,GFM2 |
| sequence-specific DNA binding | RORCA,ESR2A,FOXN2B,SOX7,HOXC5,RXRA,FOXM1,LHX1,PPARA,POUV |
| poly(A) RNA binding | SSB,PKN2,NARG1,RTCA,CRNKL1,WBSCR22,CPEB2,HHATL,ANXA2,MRPS23 |
| endoribonuclease activity | CPSF3,RNASEK,ENDOU,TSN,RNASEKA,ERN1,ENDOU2,DICER1,DROSHA,RCL1 |
| DNA binding | ATF4,POU1F1,SOX2,MLXIPL,RPL6,GPBP1,ZNF19,PPP1R10,KLF14,GM14479 |
| metal ion binding | ZRANB3,NME3,ADAT1,ZFYVE21,NR4A2B,CYP2P6,CYP2J6,TUT1,ZFP513,FBXL19 |
| protein transporter activity | AP2A1,KPNA3,ARFGAP3,IPO4,AP1S3B,SEC61G,TMCO6,CALCRL,TNPO1,CHMP7 |
| single-stranded DNA binding | OBFC2B,NEIL3,PMS1,PEO1,POLR2G,TTC6,ERCC4,BLM,PCBP1,CSDA |
Interacting Protein
TSNAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSNAX here. Most of them are supplied by our site. Hope this information will be useful for your research of TSNAX.
AIMP1;KLC3;BLOC1S5;TCF12;LZTS2
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References
- Cheng, JY; Wang, SH; et al. Globo-H Ceramide Shed from Cancer Cells Triggers Translin-Associated Factor X-Dependent Angiogenesis. CANCER RESEARCH 74:6856-6866(2014).
- Li, N; Zheng, J; et al. Identification of chimeric TSNAX-DISC1 resulting from intergenic splicing in endometrial carcinoma through high-throughput RNA sequencing. CARCINOGENESIS 35:2687-2697(2014).
