TSEN34
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Official Full Name
tRNA splicing endonuclease 34 homolog (S. cerevisiae) -
Overview
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
TSEN34;tRNA splicing endonuclease 34 homolog (S. cerevisiae);LENG5, leukocyte receptor cluster (LRC) member 5 , tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae);tRNA-splicing endonuclease subunit Sen34;SEN34;SEN34L;HsSen34;LENG 5;LENG5;Leukocyte receptor cluster (LRC) member 5;Leukocyte receptor cluster member 5;SEN 34;tRNA intron endonuclease Sen34;tRNA splicing endonuclease 34 homolog;tRNA splicing endonuclease subunit Sen34;TSEN 34;tRNA-intron endonuclease Sen34;PCH2C
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TSEN34-3444H | Recombinant Human TSEN34, GST-tagged | E.coli | Human | GST | 1-390aa | |
| TSEN34-17481M | Recombinant Mouse TSEN34 Protein | Mammalian Cells | Mouse | His |
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| TSEN34-4990R | Recombinant Rhesus monkey TSEN34 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TSEN34-721HCL | Recombinant Human TSEN34 293 Cell Lysate | HEK293 | Human | Non |
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| TSEN34-2800H | Recombinant Human TSEN34 Protein, His-tagged | E.coli | Human | His |
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| TSEN34-4804R | Recombinant Rhesus Macaque TSEN34 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| TSEN34-4804R-B | Recombinant Rhesus Macaque TSEN34 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| TSEN34-9669M | Recombinant Mouse TSEN34 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TSEN34-9669M-B | Recombinant Mouse TSEN34 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TSEN34 involved in several pathways and played different roles in them. We selected most pathways TSEN34 participated on our site, such as Gene Expression,tRNA processing,tRNA processing in the nucleus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSEN34 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | HNRNPL2,RBM5,ASZ1,ANP32A,SUZ12A,SEC61B,ZNF157,ZNF12,ZNF230,ZNF19 |
| tRNA processing | C14orf166,ADAT1,POP7,TP53RK,ADAT2,ZBTB8OS,CDKAL1,TSEN2,RPP40,XPOT |
| tRNA processing in the nucleus | RPP14,XPOT,RPP40,ELAC2,FAM98B,RPP38,TSEN15,TSEN2,C22orf28,C14orf166 |
Protein Function
TSEN34 has several biochemical functions, for example, lyase activity,nucleic acid binding,tRNA-intron endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSEN34 itself. We selected most functions TSEN34 had, and list some proteins which have the same functions with TSEN34. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lyase activity | THA1,ALDOCA,Car2,AGXT2L2,ADCY2B,FH1,ADCY1A,GUCY2E,ETNPPL,TSEN2 |
| nucleic acid binding | ZNF384L,TRERF1,ZFP354C,ACTG2,QK,ZFP131,EAR5,ZSCAN4F,SP8B,REXO1L1 |
| tRNA-intron endonuclease activity | TSEN2,TSEN15 |
Interacting Protein
TSEN34 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSEN34 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSEN34.
L1TD1;Batf3
Resources
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References
- Cassandrini, D; Biancheri, R; et al. Pontocerebellar hypoplasia Clinical, pathologic, and genetic studies. NEUROLOGY 75:1459-1464(2010).
- Bierhals, T; Korenke, GC; et al. Pontocerebellar hypoplasia type 2 and TSEN2: Review of the literature and two novel mutations. EUROPEAN JOURNAL OF MEDICAL GENETICS 56:325-330(2013).
- Graham, JM; Spencer, AH; et al. Molecular and Neuroimaging Findings in Pontocerebellar Hypoplasia Type 2 (PCH2): Is Prenatal Diagnosis Possible?. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 152A:2268-2276(2010).
