TSC2

Official Full Name

tuberous sclerosis 2
Overview

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms

TSC2;tuberous sclerosis 2;LAM;TSC4;tuberin;tuberous sclerosis 2 protein

Recombinant Proteins

Type:

Recombinant Proteins

Protein Pre-coupled Magnetic Beads

Filters:

Species

Human
Zebrafish
Rat

Source

E.coli
Mammalian Cells
HEK293

Tag

His
Avi&Fc&His

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
TSC2-35H	Recombinant Human TSC2 protein, His-tagged	E.coli	Human	His	1459-1807 aa	$319 / 25μg
TSC2-31631TH	Recombinant Human TSC2, His-tagged	E.coli	Human	His	1396-1725 a.a.	Inquiry
TSC2-4633Z	Recombinant Zebrafish TSC2	Mammalian Cells	Zebrafish	His		Inquiry
TSC2-6310R	Recombinant Rat TSC2 Protein	Mammalian Cells	Rat	His		Inquiry
TSC2-6386Z	Recombinant Zebrafish TSC2	Mammalian Cells	Zebrafish	His		Inquiry
TSC2-5967R	Recombinant Rat TSC2 Protein, His (Fc)-Avi-tagged	HEK293	Rat	Avi&Fc&His		Inquiry
TSC2-5967R-B	Recombinant Rat TSC2 Protein Pre-coupled Magnetic Beads	HEK293	Rat			Inquiry

Involved Pathway

TSC2 involved in several pathways and played different roles in them. We selected most pathways TSC2 participated on our site, such as Phospholipase D signaling pathway,p signaling pathway,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
p signaling pathway	TP53,CYCSB,TNFRSF10B,CD82B,SIAH1A,CCND3,BBC3,CASP3B,CCND2,GADD45AB
Choline metabolism in cancer	PRKCA,DGKQ,DGKE,PDGFC,PLA2G4B,PIK3R2,SLC22A5,MAPK9,HIF1A,PIK3R5
Thyroid hormone signaling pathway	RXRB,GSK3B,RXRG,RXRA,PLCB4,SRC,ATP1A1,MED13L,KAT2B,PDPK1
AMPK signaling pathway	ADIPOQ,PFKM,LEP,RPTOR,PPP2CA,MAP3K7,ADRa1A,ACACA,CREB3,EEF2K
Insulin signaling pathway	PRKAB1,PRKAR1AB,CALM,RAPGEF1B,RPS6KB1B,EIF4E2RS1,CALML5,ELK1,PRKAA1,IRS2
mTOR signaling pathway	RPS6KA3,TSC1A,AKT3A,PIK3CD,MAPK1,CAB39,AKT1,PRKCG,STK11,AKT1S1
PIK-Akt signaling pathway	TRP53,GNG8,SOS1,FGF4,GNG2,PPP2R1B,IFNA21,IFNAR2,CCNE2,FGF13
Phospholipase D signaling pathway	GNAS,PIK3R3,CXCR1,MRAS,PLD2,GRM5,PIP5K1A,PIK3R1,KITLG,PDGFB

Protein Function

TSC2 has several biochemical functions, for example, 14-3-3 protein binding,GTPase activator activity,phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TSC2 itself. We selected most functions TSC2 had, and list some proteins which have the same functions with TSC2. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	LLGL2,ARAP2,RALBP1,RANBP1,ARHGAP9,IQGAP3,ASAP2B,AGAP2,ARHGDIB,TBC1D7
protein homodimerization activity	NRF1,RIPK2,MGST1,SDCBP2,FZD9,EXT1,APOE,SLC11A1,GTF2A2,DMRT3
14-3-3 protein binding	RPTOR,YWHAQ,PRKCZ,DDIT4,KCNH1,PRKCE,AKT1,SRPK2,HDAC7,IRS2
protein binding	SP3,MCC,NOL9,ZFAND5,AIRE,MED22,LLGL1,RPS6,USP15,PPIG
phosphatase binding	PPARA,DLG1L,TRPC4AP,SLC9A3R2,PPP1R35,PPP1R32,PPP1R21,DYSFIP1,DZIP3,DLG3
small GTPase binding	RCC2,PEX5L,FGD6,PEX5,FGD3,ERRFI1,FGD2,GDI2,RNF152,ABCA1

Interacting Protein

TSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TSC2.

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