TRPV4
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Official Full Name
transient receptor potential cation channel, subfamily V, member 4 -
Overview
a cation-selective channel; activated in response to systemic osmotic pressure -
Synonyms
TRPV4;transient receptor potential cation channel, subfamily V, member 4;transient receptor potential cation channel subfamily V member 4;CMT2C;osmosensitive transient receptor potential channel 4;OTRPC4;TRP12;VR OAC;VRL 2;VROAC;osm-9-like TRP c
Recombinant Proteins
- Mouse
- Zebrafish
- Chicken
- Rat
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPV4-17463M | Recombinant Mouse TRPV4 Protein | Mammalian Cells | Mouse | His |
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| TRPV4-3831Z | Recombinant Zebrafish TRPV4 | Mammalian Cells | Zebrafish | His |
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| TRPV4-6258C | Recombinant Chicken TRPV4 | Mammalian Cells | Chicken | His |
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| TRPV4-6305R | Recombinant Rat TRPV4 Protein | Mammalian Cells | Rat | His |
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| TRPV4-730HCL | Recombinant Human TRPV4 293 Cell Lysate | HEK293 | Human | Non |
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| TRPV4-731HCL | Recombinant Human TRPV4 293 Cell Lysate | HEK293 | Human | Non |
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| TRPV4-1177HFL | Recombinant Human TRPV4 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-824 aa |
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| TRPV4-5962R | Recombinant Rat TRPV4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TRPV4-5962R-B | Recombinant Rat TRPV4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TRPV4-9661M | Recombinant Mouse TRPV4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TRPV4-9661M-B | Recombinant Mouse TRPV4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TRPV4 involved in several pathways and played different roles in them. We selected most pathways TRPV4 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | IL1RAP,PTGER2,P2RY2,IL1B,MAPK9,ASIC2,HTR2B,BDKRB2,IL1R1,HTR2A |
Protein Function
TRPV4 has several biochemical functions, for example, ATP binding,SH2 domain binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV4 itself. We selected most functions TRPV4 had, and list some proteins which have the same functions with TRPV4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH2 domain binding | JAK2,NLK,LCK,SRC,SYP,SKAP1,SQSTM1,AFAP1L2,CRK,SHCBP1 |
| actin binding | PTK2,TNS4,PARVA,DIAP1,MTAP1A,NRAP,EPS8L2,ACTN2B,DNASE1,MYH8 |
| microtubule binding | BCL2L11,FAM83D,DPYSL5B,KIF20A,PRC1A,DPYSL2,KIF3C,KIF5B,NEFM,SPAST |
| beta-tubulin binding | PIFO,GABARAP,MAP1S,NDEL1,CASC1,SPAST,ARL8B,RANBP10,PEX14,UXT |
| calcium channel activity | GRIN2B,TRPV5,TMEM37,CHRNA9,TPCN1,TRPV1,GRIN2A,RYR2,CHRNA10,PDE2A |
| protein binding | DCSTAMP,GK,LEPROT,MAPKAPK2,C11orf57,PARP2,HHLA3,MAFB,HBXIP,AKT1S1 |
| protein kinase binding | CHRNA7,CHEK2,HDAC4,LAT,SOCS1,GPRC5B,USF1,MAP2K3,TBL2,TBC1D14 |
| cation channel activity | CALHM2,FAM38A,GRIN2C,ASIC4A,CALHM3,FAM26F,PKD2L1,TRPM1,GRIN3B,GRIN2A |
| calmodulin binding | CNGA2,PPP3R1,MKNK2,SLC8A1,PHKG1A,DAPK1,SMTNL1,PHKB,KCNN1A,RGS4 |
Interacting Protein
TRPV4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV4.
HIF1AN;RAN;ouabain;ARRB2;CANX
Resources
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References
- Dussor, G; Yan, J; et al. Targeting TRP Channels For Novel Migraine Therapeutics. ACS CHEMICAL NEUROSCIENCE 5:1085-1096(2014).
- Lee, JC; Choe, SY; et al. Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats. JOURNAL OF MOLECULAR HISTOLOGY 45:497-505(2014).
