TRPM6

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    transient receptor potential cation channel, subfamily M, member 6
  • Overview

    TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.
  • Synonyms

    TRPM6;transient receptor potential cation channel, subfamily M, member 6;HOMG, HSH, hypomagnesemia, secondary hypocalcemia;transient receptor potential cation channel subfamily M member 6;CHAK2;FLJ22628;channel kinase 2;melastatin-related TRP cati
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPM6-8098Z Recombinant Zebrafish TRPM6 Mammalian Cells Zebrafish His
TRPM6-824H Recombinant Human TRPM6 Mammalian Cells Human His
TRPM6-1168HFL Recombinant Human TRPM6 protein, His&Flag-tagged HEK293 Human Flag&His 1-2017 aa
TRPM6-4248H Recombinant Human TRPM6 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
TRPM6-4248H-B Recombinant Human TRPM6 Protein Pre-coupled Magnetic Beads HEK293 Human

Involved Pathway

TRPM6 involved in several pathways and played different roles in them. We selected most pathways TRPM6 participated on our site, such as Ion channel transport,Mineral absorption,Stimuli-sensing channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transport TPCN1,SLC9B2,TRPC4,ASPH,ANO8,ATP10A,FXYD3,CLCN1,CCC2,CUTC
Stimuli-sensing channels ANO5,MCOLN2,SLC9A10,TPCN1,TRPC4AP,CLCNKA,ANO10A,TTYH2,CLCN1,TRPM4C
Mineral absorption MT1X,HMOX2,MT1E,VDR,SLC8A1,CLCN2,MT1B,ATP1A1,SLC26A9,HEPH
TRP channels TRPC4APB,TRPA1A,TRPA1B,TRPM1,TRPM4A,TRPC4A,MCOLN2,TRPC5A,TRPC4,TRPM1B
Transmembrane transport of small molecules TRPV3,NIPAL3,SLC5A2,RHCG2A,GLRBA,ATP7B,SLC2A7,SLC41A1,AQP10B,CLCN5

Protein Function

TRPM6 has several biochemical functions, for example, ATP binding,calcium channel activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM6 itself. We selected most functions TRPM6 had, and list some proteins which have the same functions with TRPM6. You can find most of the proteins on our site.

Function Related Protein
protein serine/threonine kinase activity TTBK2,PRKCI,SPEG,MAP2K2,RIOK3,CASK,STK4,BMPR2A,LIMK1,CAMK2G1
ATP binding PTK2AB,SKIV2L,RAD50,ROCK2A,THRAP3,PKN1,RUVBL1,MYH9,KCNJ1,ATP13A1
metal ion binding ZC2HC1A,ECE2,KCNIP3B,NR1D2A,CYP1A,PDE4B,HDAC5,DMRTC2,ARHGEF28,KCND1
protein binding AHCYL2,CACNG1,NKD1,MME,HTATIP2,POLR1B,MGRN1,Apba1,RAB9B,ARHGAP44
calcium channel activity CACNA1BA,TRPM8,CACNA2D3,TRPM2,PSEN1,TRPV4,GRIN2A,SLC24A1,SLC24A2,TRPV6

Interacting Protein

TRPM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM6.

MYH9;MYH10;MYH14

Resources

References

  • Costa, A; Tejpar, S; et al. Hypomagnesaemia and targeted anti-epidermal growth factor receptor (EGFR) agents. TARGETED ONCOLOGY 6:227-233(2011).
  • Dimke, H; van der Wijst, J; et al. Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 21:1309-1316(2010).

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