TRPM5
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Official Full Name
transient receptor potential cation channel, subfamily M, member 5 -
Overview
This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. -
Synonyms
TRPM5;transient receptor potential cation channel, subfamily M, member 5;transient receptor potential cation channel subfamily M member 5;LTRPC5;MTR1;9430099A16Rik;Long transient receptor potential channel 5;MLSN1 and TRP related gene 1;MLSN1 and TRP related gene 1 protein;MLSN1 and TRP-related;Novel protein similar to vertebrate transient receptor potential cation channel, subfamily M, member 5;TRPM5 transient receptor potential cation channel, subfamily M, member 5;LTrpC-5;MLSN1- and TRP-related gene 1 protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPM5-3435H | Recombinant Human TRPM5, GST-tagged | E.coli | Human | GST | 1-350aa | |
| TRPM5-17456M | Recombinant Mouse TRPM5 Protein | Mammalian Cells | Mouse | His |
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| TRPM5-6813Z | Recombinant Zebrafish TRPM5 | Mammalian Cells | Zebrafish | His |
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| TRPM5-1167HFL | Recombinant Human TRPM5 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-1165 aa |
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| TRPM5-9657M | Recombinant Mouse TRPM5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TRPM5-9657M-B | Recombinant Mouse TRPM5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TRPM5 involved in several pathways and played different roles in them. We selected most pathways TRPM5 participated on our site, such as Taste transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Taste transduction | TAS2R110,SCNN1G,TAS2R20,TAS2R16,SCNN1B,TAS2R143,GNG13,PLCB2,TAS2R140,TAS2R139 |
Protein Function
TRPM5 has several biochemical functions, for example, calcium activated cation channel activity,ion channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM5 itself. We selected most functions TRPM5 had, and list some proteins which have the same functions with TRPM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel activity | TRPM4A,KCNC1B,SCN8AB,CLCNKB,TRPC5A,KCNC1A,CACNA1C,TRPM1,TRPC6A,GRIA3A |
| potassium channel activity | TMEM38B,KCNG4A,KCNK5,KCNC3B,KCNG1,ABCC9,KCNIP4,KCNA2,KCNK9,KCNC1A |
| voltage-gated ion channel activity | CLIC4,PKD2,CACNA2D3,KCNC2,CACNA1BA,KCNK10,KCNJ11L,CX35B,SCN12AB,KCNK4 |
| calcium activated cation channel activity | TRPM4,PKD2L1,CATSPER2,CALHM1,ANO6,TMEM63C,TRPM4A,CATSPER1,ANO10,TRPM4C |
| sodium channel activity | TRPM2,SCN1LAB,ACCN3,ASIC1C,SCN12AA,SCN8AB,ASIC4B,SLC4A11,ACCN4,KCNK1 |
Interacting Protein
TRPM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM5.
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References
- Panneck, AR; Rafiq, A; et al. Cholinergic epithelial cell with chemosensory traits in murine thymic medulla. CELL AND TISSUE RESEARCH 358:737-748(2014).
- Eberle, JAM; Richter, P; et al. Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication. FRONTIERS IN PHYSIOLOGY 4:-(2013).
