TRPM4
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Official Full Name
transient receptor potential cation channel, subfamily M, member 4 -
Overview
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent;cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with;increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants;encoding different isoforms have been found for this gene. -
Synonyms
TRPM4;transient receptor potential cation channel, subfamily M, member 4;transient receptor potential cation channel subfamily M member 4;FLJ20041;LTrpC4;hTRPM4;melastatin-4;long transient receptor potential channel 4;calcium-activated non-selecti
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Flag
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TRPM4 involved in several pathways and played different roles in them. We selected most pathways TRPM4 participated on our site, such as Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin secretion | SNAP25,PLCB4,SLC2A1,CREB3L2,STX1A,Adcy4,GCG,CAMK2G,PRKACG,PLCB1 |
Protein Function
TRPM4 has several biochemical functions, for example, ATP binding,calcium activated cation channel activity,calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM4 itself. We selected most functions TRPM4 had, and list some proteins which have the same functions with TRPM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | RYR3,ADD2,EDF1,GM101,MYO10,MYO5A,MYO9B,CNGA2,ITPKB,KCNN3 |
| ATP binding | NRBP1,CKBB,MERTK,ATAD5,ATP8B5,TOR1L3,PANK4,FGFR1A,ATP2B2,PIK3CA |
| calcium channel activity | TRPV2,TRPM2,TRPM6,TRPC3,CACNA1SB,TMEM37,SLC24A2,PDE2A,TRPC5A,CACNA1BA |
| calcium activated cation channel activity | TRPM5,TMEM63C,ANO6,TRPM4A,CATSPER1,CALHM1,ANO10,TRPM4C,PKD2L1,CATSPER2 |
Interacting Protein
TRPM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM4.
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References
- Burt, R; Graves, BM; et al. 9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes. CELL CALCIUM 54:193-201(2013).
- Teruyama, R; Sakuraba, M; et al. Transient Receptor Potential Channel M4 and M5 in Magnocellular Cells in Rat Supraoptic and Paraventricular Nuclei. JOURNAL OF NEUROENDOCRINOLOGY 23:1204-1213(2011).
