TRPM1
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Official Full Name
transient receptor potential cation channel, subfamily M, member 1 -
Overview
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. -
Synonyms
TRPM1;transient receptor potential cation channel, subfamily M, member 1;melastatin 1 , MLSN1;transient receptor potential cation channel subfamily M member 1;LTRPC1;melastatin-1;long transient receptor potential channel 1;transient receptor potent
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPM1-17452M | Recombinant Mouse TRPM1 Protein | Mammalian Cells | Mouse | His |
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| TRPM1-6300R | Recombinant Rat TRPM1 Protein | Mammalian Cells | Rat | His |
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| TRPM1-5957R | Recombinant Rat TRPM1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| TRPM1-5957R-B | Recombinant Rat TRPM1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| TRPM1-764H | Recombinant Human TRPM1 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1127-1603a.a. |
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| TRPM1-9655M | Recombinant Mouse TRPM1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TRPM1-9655M-B | Recombinant Mouse TRPM1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TRPM1 involved in several pathways and played different roles in them. We selected most pathways TRPM1 participated on our site, such as Ion channel transport,Stimuli-sensing channels,TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stimuli-sensing channels | TPCN1,CLCN4-2,ASIC1A,CLCN5,CLCN1A,ANO5,BEST1,TTYH3,MCOLN3,OSTM1 |
| Ion channel transport | ANO7,GLRBA,TRPM1B,ATP1A1A.2,ATP2C2,ATP1A1A.4,CLCNK,CLCN5,SRI,ANO1 |
| TRP channels | TRPM1B,TRPV3,TRPA1A,TRPC4AP,TRPA1B,TRPC4,TRPM6,TRPM4C,TRPC4APA,TRPC5 |
| Transmembrane transport of small molecules | SCNN1D,CLCN6,SLC38A5B,ATP13A5,ABCE1,PIP,SLC1A7A,SLC29A3,SLC38A4,SLC6A1B |
Protein Function
TRPM1 has several biochemical functions, for example, calcium channel activity,cation channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPM1 itself. We selected most functions TRPM1 had, and list some proteins which have the same functions with TRPM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cation channel activity | GRIN2A,PKD1,TRPM1A,TRPV4,P2RX1,FAM38B,CALHM3,PKD2L1,ASIC4B,FAM26D |
| ion channel activity | SCN11A,CHRNA10A,SCNN1G,KCNA6A,CLCNK,KCNC2,CNGA5,P2RX8,TRPM4C,CACNA1DA |
| calcium channel activity | TRPV2,CACFD1,RYR1B,ITPR3,PSEN1,TRPC4A,CACNG1A,P2RX1,CUL5,CACNA2D3 |
Interacting Protein
TRPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPM1.
Resources
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References
- Brown, RL; Xiong, WH; et al. TRPM3 Expression in Mouse Retina. PLOS ONE 10:-(2015).
- Agosto, MA; Zhang, ZX; et al. Oligomeric State of Purified Transient Receptor Potential Melastatin-1 (TRPM1), a Protein Essential for Dim Light Vision. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27019-27033(2014).
