TRPC7
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Official Full Name
transient receptor potential cation channel, subfamily C, member 7 -
Overview
Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a human gene encoding a protein of the same name. -
Synonyms
TRPC7;transient receptor potential cation channel, subfamily C, member 7;short transient receptor potential channel 7;Capacitative calcium channel TRPC7;cation channel, subfamily C, member 7;hTRP7;KNP3;Likley ortholog of mouse transient receptor potential cation channel subfamily C member 7;mTRP7;Putative capacitative calcium channel;Transient receptor potential cation channel subfamily C member 7;transient receptor potential-related channel 7, a novel putative Ca2+ channel protein;Transient receptor protein 7;TRP 7;TRP-7;TRP7 protein;TRPC 7;Trpc7 transient receptor potential cation channel, subfamily C, member 7;TRPC7_HUMAN;TRPM2;Trrp8;OTTHUMP00000221120;OTTHUMP00000221122;OTTHUMP00000221124;OTTHUMP00000221125;likley ortholog of mouse transient receptor potential c;TRP7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPC7-3433H | Recombinant Human TRPC7, His-tagged | E.coli | Human | His | 721-781aa | |
| TRPC7-740HCL | Recombinant Human TRPC7 293 Cell Lysate | HEK293 | Human | Non |
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| TRPC7-1163HFL | Recombinant Human TRPC7 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-746 aa |
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Involved Pathway
TRPC7 involved in several pathways and played different roles in them. We selected most pathways TRPC7 participated on our site, such as Axon guidance,Developmental Biology,Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | CAP2,CLASP1,MED23,MED22,ARPC2,COL9A1B,AP2A2,COL4A3,FGF18B,PTPRA |
| Effects of PIP2 hydrolysis | ABHD6B,DGKA,MGLL,DGKQ,RASGRP2,TRPC3,TAE1,DGKB,DGKG,ABHD12 |
| Axon guidance | MYL9,FRS2A,NRG3,RGS3,DNM2,CSF2RA,NTN4,SEMA3G,RHOB,PLXNB2 |
| Gastrin-CREB signalling pathway via PKC and MAPK | UTS2,PROK2,KISS1,GPR132B,FPR-RS4,ANXA1A,TAC3,QRFPR,TRIO,LPAR2B |
| Elevation of cytosolic Ca2+ levels | TRPC6A,TRPC3 |
| Hemostasis | ITGB3A,RAPGEF4,ITPK1,DOCK6,WDR1,MFN2,CALU,BA1,GLG1B,KIF5A |
| G alpha (q) signalling events | HCRT,EDNRAB,MGLL,GRP,ARHGEF25,GCGA,TRPC6A,QRFPR,NPFFR2,CHRM3 |
| GPCR downstream signaling | VIP2,OPN1LW1,NMBA,INSL5,OR4D2,TRIO,PTHLHA,PROK1,CNR2,OPN1LW2 |
Protein Function
TRPC7 has several biochemical functions, for example, inositol 1,4,5 trisphosphate binding,protein binding,store-operated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC7 itself. We selected most functions TRPC7 had, and list some proteins which have the same functions with TRPC7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| store-operated calcium channel activity | TRPC6,STIM2,TRPC2,TRPC5,ORAI1,ORAI3,TRPC3,ORAI2,TRPC4,ORAI1B |
| protein binding | SOCS7,ADM,NR1H3,BMPR1AA,PFDN2,MOB4,ZNF664-FAM101A,AZIN1,SIRT2,CHMP2B |
| inositol 1,4,5 trisphosphate binding | RPH3A,PLCL1,CYTH2,TRPC6,TRPC7A,TRPC4,TRPC6A,TRPC3,TRPC5,TRPC2B |
Interacting Protein
TRPC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC7.
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References
- Tabarean, IV; et al. Persistent Histamine Excitation of Glutamatergic Preoptic Neurons. PLOS ONE 7:-(2012).
- Cvetkovic-Lopes, V; Eggermann, E; et al. Rat Hypocretin/Orexin Neurons Are Maintained in a Depolarized State by TRPC Channels. PLOS ONE 5:-(2010).
