TRPC5

  • Official Full Name

    transient receptor potential cation channel, subfamily C, member 5

  • Overview

    This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).

  • Synonyms

    TRPC5;transient receptor potential cation channel, subfamily C, member 5;short transient receptor potential channel 5;transient receptor protein 5;Trrp5
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPC5-742HCL Recombinant Human TRPC5 293 Cell Lysate HEK293 Human Non
RFL34046BF Recombinant Full Length Bovine Short Transient Receptor Potential Channel 5(Trpc5) Protein, His-Tagged E.coli Bovine His Full L. Full Length (1-109)
TRPC5-01H Recombinant Human TRPC5 Protein (A2-L973 end), N-8×His-MBP-TEV and C-Flag-tagged Mammalian Cells Human His&Flag&MBP A2-L973 end
TRPC5-1161HFL Recombinant Human TRPC5 protein, His&Flag-tagged HEK293 Human His&Flag 1-973 aa
TRPC5-1269H Recombinant Human TRPC5 Protein (A2-L973 end), 8×His-MBP, Flag tagged Mammalian Cells Human His&Flag&MBP A2-L973 end

    Involved Pathway

    TRPC5 involved in several pathways and played different roles in them. We selected most pathways TRPC5 participated on our site, such as Axon guidance,Developmental Biology,Ion channel transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TRP channels TRPV3,TRPC4AP,TRPM6,MCOLN2,TRPC4B,TRPC5A,MCOLN3,TRPM1,TRPM4C,TRPC4
    Ion channel transport TRPM6,MCOLN2,CLCN4-2,ASPH,ANO10,ATP8B1,FKBP1B,GLRBA,CLCN2,TRPM4A
    Netrin-1 signaling RGMA,SIAH2,PITPNA,RNF8,NTN1B,RGMB,NTN1A,UNC5D,HFE2,TRPC4
    Stimuli-sensing channels CLCN4,ANO9,TRPM4C,ASPH,ANO5,SRI,MCOLN2,TRPM1B,SLC9A10,TRPA1B
    Axon guidance EFNA4,CD24,KALRN,EPHA4A,NRP1,RASA1,HBEGF,SEMA7A,PTPRA,SPRED1
    Developmental Biology SPRED2,EPHA10,UNC5D,KLB,MYL12A,CACNG3,FRS2A,FOXH1,AP2A1,NADL1.1
    Transmembrane transport of small molecules EPB49,CLCN7,CLCN4-2,SLC2A10,SLC22A16,ATP2B1B,SLC7A3A,SLC30A5,SLC20A1,SLC1A7B
    Role of second messengers in netrin-1 signaling PITPNA,TRPC4

    Protein Function

    TRPC5 has several biochemical functions, for example, calcium channel activity,inositol 1,4,5 trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC5 itself. We selected most functions TRPC5 had, and list some proteins which have the same functions with TRPC5. You can find most of the proteins on our site.

    Function Related Protein
    store-operated calcium channel activity TRPC6A,TRPC1,TRPC7,TRPC7A,TRPC6,ORAI2,ZP3,TRPC3,ORAI1,ORAI1B
    calcium channel activity CHRNA10,TRPC6A,RYR1B,PANX1,TRPC7B,CACNG1A,SLC24A2,CATSPER2,TRPC7A,GRIN3A
    protein binding C2orf28,USP13,LYAR,TCEB3,MCPH1,RPL23,BSCL2,TNFRSF6B,TMEM14C,INTS7
    inositol 1,4,5 trisphosphate binding TRPC6,RPH3A,ITPR3,TRPC3,PLCL1,AKR1C1,TRPC1,TRPC2B,TRPC6A,CYTH2

    Interacting Protein

    TRPC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC5.

    MX1

    Resources

    References

    • Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).
    • Tabarean, IV; et al. Persistent Histamine Excitation of Glutamatergic Preoptic Neurons. PLOS ONE 7:-(2012).

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