TRPC3
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Official Full Name
transient receptor potential cation channel, subfamily C, member 3 -
Overview
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
TRPC3;transient receptor potential cation channel, subfamily C, member 3;TRP3;short transient receptor potential channel 3;hTrp-3;transient receptor protein 3;transient receptor potential cation channel subfamily C member 3 variant c
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPC3-4609C | Recombinant Chicken TRPC3 | Mammalian Cells | Chicken | His |
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| TRPC3-8414Z | Recombinant Zebrafish TRPC3 | Mammalian Cells | Zebrafish | His |
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| TRPC3-745HCL | Recombinant Human TRPC3 293 Cell Lysate | HEK293 | Human | Non |
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| TRPC3-1159HFL | Recombinant Human TRPC3 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-921 aa |
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| TRPC3-6113H | Recombinant Human TRPC3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Trpc3-6676M | Recombinant Mouse Trpc3 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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Involved Pathway
TRPC3 involved in several pathways and played different roles in them. We selected most pathways TRPC3 participated on our site, such as Axon guidance,Developmental Biology,Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (q) signalling events | NPFFR2,QRFPR,PROK1,GPR68,NMB,LPAR2B,NPS,RGS21,OPN4.1,DGKQ |
| Axon guidance | SPRED3,SEMA6D,SEMA3D,SPRED2,WDR83,ACTR3,FRS3,COL4A5,EFNA5,PEA15A |
| Hemostasis | KIF3B,BSG,F9B,MAFG,PDE10A,GRB14,CD9B,CABLES2,D-AKAP2,GRB7 |
| Gastrin-CREB signalling pathway via PKC and MAPK | OPN4.1,TAC1,FPR-RS6,RGS18,GPR132,PROKR1,EDN2,NMBA,TAC2,FFAR3 |
| Developmental Biology | IL17RD,EPHB4B,CAP2,AP2M1,HFE2,SMAD3B,PLXNC1,DLG3,POU5F3,COL6A3 |
| Effects of PIP2 hydrolysis | ABHD12,DGKG,DGKQ,TAE1,TRPC7,DGKB,RASGRP2,PRKCHB,MGLL,DGKA |
| GPCR downstream signaling | FPR-RS4,ANXA1C,PROKR2,RAMP2,VIP2,CHRM2,EDN3,UTS2,LPAR2A,KISS1 |
| Elevation of cytosolic Ca2+ levels | TRPC6A,TRPC7 |
Protein Function
TRPC3 has several biochemical functions, for example, calcium channel activity,inositol 1,4,5 trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC3 itself. We selected most functions TRPC3 had, and list some proteins which have the same functions with TRPC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol 1,4,5 trisphosphate binding | TRPC7,CYTH2,TRPC7A,TRPC2B,TRPC4,AKR1C1,PLCL1,TRPC6A,RPH3A,TRPC1 |
| protein binding | ARFGAP1,RALYL,EPHB4,PHB2,SH3PXD2A,LINC00482,PPP6R2,ZNF397,CCDC42,TNNI1 |
| store-operated calcium channel activity | TRPC1,TRPC7A,TRPC6A,ORAI3,ORAI1B,TRPC5,TRPC2,ORAI1,ORAI2,TRPC2B |
| calcium channel activity | SLC24A4A,TRPC4A,CACNA2D3,AKR1C1,TRPC5A,SLC24A4,TRPC5,CACNG2B,UBXN6,CACNG7A |
Interacting Protein
TRPC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC3.
ITPR3;MX1;Plcg1
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References
- Xie, YF; Zhou, FM; et al. TRPC3 channel mediates excitation of striatal cholinergic interneurons. NEUROLOGICAL SCIENCES 35:1757-1761(2014).
- Zhou, FW; Roper, SN; et al. TRPC3 mediates hyperexcitability and epileptiform activity in immature cortex and experimental cortical dysplasia. JOURNAL OF NEUROPHYSIOLOGY 111:1227-1237(2014).
