Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway TBL1XR1,SFRP5,RAC3,RHOAA,FBXW2,PPARD,NLK,CUL1B,PPP3R2,SFRP1A
    Thyroid hormone signaling pathway HRAS,RXRB,FOXO1,PLCZ1,DIO2,MED14,ATP2A2,PLCG2,MED30,KAT2A
    HTLV-I infection PDGFB,STAT5B,TRP53INP1,HLA-DRB1,WNT8B,EGR1,POLD4,LTBR,WNT3,POLE4
    Huntingtons disease POLR2C,NDUFB9,NDUFB6,ATP5J,CREB3L1,GRM5,GRIN1,CYCS,NDUFC2-KCTD14,PLCB1
    p signaling pathway SHISA5,CASP3A,GADD45BB,PPM1DA,STEAP3,SESN1,TP53,CCNG2,RRM2B,LRDD
    Viral carcinogenesis PIK3R1,PIK3R2,HDAC11,YWHAG,UBR4,MAD1L1,HDAC4,GTF2H1,HLA-A,ATF4
    Bladder cancer RPS6KA5,MAPK3,RAF1,E2F2,MDM2,KRAS,CDH1,ERBB2,FGFR3,E2F3
    Pancreatic cancer RB1,RAC2,RAC1,CCND1,MAPK3,VEGFA,PIK3CB,TGFB2,PIK3R5,IKBKG
    Pathways in cancer MITF,CDH1,MAPK8,Flt3l,AXIN1,FGF6,PRKACA,PLCG1,FGF7,BAX

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding NFE2,UNC13A,RPA2,PEX19,EIF5A,HAX1,STXBP1,GLRX,PHB2,SMARCE1
    ubiquitin protein ligase binding Fzd4,STUB1,UBE2W,FLJ11011L,PRKAR2B,PIAS4,UBE2KA,HM13,PIAS2,TRAF3
    transcription cofactor binding FOXO3,KLF4,CHD6
    RNA polymerase II core promoter sequence-specific DNA binding TFAP2B,WBP2,NLRC5,ZNF277,TAL1,STAT6,ZFP335,SMYD3,SMAD5,MITF
    chaperone binding PFDN4,AMFR,ATP1A1,DNLZ,ERP29,TBCC,DNAJA3B,CALR,DNAJA2L,H2-KE2
    RNA polymerase II transcription factor activity, sequence-specific DNA binding ETV6,ZNF174,CC2D1A,SOX5,FEV,EF1,TFE3A,FOXA,FOXO4,EOMESA
    RNA polymerase II transcription factor binding GSK3B,SPI1,TAL1,KDM1A,GATA1,MEF2A,ANKRD1,SPOP,CREBBP,DHX9
    double-stranded DNA binding AIM2,TARDBP,TDG,RAD51L3,LSM14A,NKX2-8,USF1,GATA1A,SATB1,MRE11A
    protease binding INSL3,CST3,CAST,SRI,THAP5,TIMP2,IL1R1,SERPINB9,A2M,CFLAR

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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