Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid cancer TCF7L2,TFG,TPR,MAP2K1,HRAS,MAPK1,CCDC6,PAX8,RXRB,RXRA
    HTLV-I infection PRKACA,POLD1,IL15RA,Adcy4,PDGFRA,IKBKB,ATF4,FZD2,CALR,HLA-E
    Non-small cell lung cancer TGFA,CCND1,AKT1,BRAF,ARAF,SOS1,HRAS,PIK3CD,RASSF5,NRAS
    Apoptosis HIST1H1D,PIK3CD,DSG3,CDKN2A,CYCSB,FAS,CASP6L1,RIPK1L,DSG1,PRKAR1AB
    Hepatitis B EGR2,BCL2,IFNAR1,MAVS,IFNA10,MAP2K1,RAF1,HSPG2,CCND1,CREB3L3
    Pancreatic cancer BRCA2,MAPK3,PIK3CB,TGFA,PIK3R2,PIK3R1,MAPK10,MAPK1,STAT3,RALB
    Herpes simplex infection HLA-DOB,SRSF9,PTPN11A,HLA-DMB,IL12B,SRPK1A,BLB2,SRSF1B,CRFB2,CASP3B
    Measles CD3E; CD3D,IFNA21,EIF3H,TP53,EIF2AK2,CD209C,PRKCQ,STAT5A,IFNA17,MAP3K7
    Thyroid hormone signaling pathway ATP1B4,ATP1A4,THRA,DIO3,RXRG,PLCB3,PIK3R3,HDAC2,BMP4,MED27

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding GATA1A,SPI1,ANKRD1,Ar,GATA2B,TBX6,SMAD4,GATA2,PITX2,GATA6
    transcription cofactor binding FOXO3,KLF4,CHD6
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ATF2,NFKB2,SMAD2,MEOX2,SIX4,ATF4,PATZ1,ZFAT,POU2F2,GABPA
    protein heterodimerization activity SYCP3,MCL1,SMC1A,AOC3,HMG20B,CAV1,CD3D,HIST1H2BH,CRLF1,TYR
    DNA binding RNF11,TCEB3C,GLIS2,ZNF493,DHX36,MLLT10,ZNF688,IMPDH1,HMGXB4,ENO1
    ubiquitin protein ligase binding HDAC6,TCEB2,SMC6,UBXN1,BAG5,CDC34A,CUL5,EGFR,PIAS4,USP13
    enzyme binding HSPA8,PIAS3,CFTR,TTN,STC2,NPM2,POR,C2orf56,PDCD2,TBP
    sequence-specific DNA binding POU3F3A,LMX1A,SIX1,FOXG1,SPI1B,ARGFX,TFAP4,NKX6-1,DMRT2B,NR1D4A
    protein phosphatase binding ITGA1,GRB2,CTNNB1,KAT2A,PIK3R2,KCNN4,MAP3K5,TP53,VCAN,SNX3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *