TRNT1
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Official Full Name
tRNA nucleotidyl transferase, CCA-adding, 1 -
Overview
The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the;3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated;and to participate in protein biosynthesis (Lizano et al., 2007 (PubMed 17204286)). -
Synonyms
TRNT1;tRNA nucleotidyl transferase, CCA-adding, 1;CCA tRNA nucleotidyltransferase 1, mitochondrial;CCA1;CGI 47;MtCCA;AA408384;C76540;CCA adding;EC 2.7.7.25;Mitochondrial CCA adding tRNA nucleotidyltransferase;Mitochondrial tRNA nucleotidyl transferase, CCA adding;mt CCA adding enzyme;mt Trat;mt tRNA adenylyltransferase;mt tRNA CCA diphosphorylase;mt tRNA CCA pyrophosphorylase;MTO2;TRMU;tRNA nucleotidyl transferase;tRNA nucleotidyl transferase CCA adding 1;OTTHUMP00000195199;OTTHUMP00000206931;OTTHUMP00000207297;mt CCA-adding enzyme;mt tRNA CCA-diphosphorylase;mt tRNA CCA-pyrophosphorylase;tRNA-nucleotidyltransferase 1, mitochondrial;mitochondrial CCA-adding tRNA-nucleotidyltransferase;mitochondrial tRNA nucleotidyl transferase, CCA-adding;CGI-47
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRNT1-17428M | Recombinant Mouse TRNT1 Protein | Mammalian Cell | Mouse | His |
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| TRNT1-383Z | Recombinant Zebrafish TRNT1 | Mammalian Cell | Zebrafish | His |
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| TRNT1-749HCL | Recombinant Human TRNT1 293 Cell Lysate | HEK293 | Human | Non |
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| TRNT1-2182H | Recombinant Human TRNT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Trnt1-6670M | Recombinant Mouse Trnt1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| TRNT1-9645M | Recombinant Mouse TRNT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| TRNT1-9645M-B | Recombinant Mouse TRNT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
TRNT1 involved in several pathways and played different roles in them. We selected most pathways TRNT1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF2S2,POP1,POP4,EIF3C,EIF1AXB,NUP210L,NCBP1,EIF1,EIF4A1B,NMD3 |
Protein Function
TRNT1 has several biochemical functions, for example, ATP binding,ATP:3-cytidine-cytidine-tRNA adenylyltransferase activity,CTP:3-cytidine-tRNA cytidylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRNT1 itself. We selected most functions TRNT1 had, and list some proteins which have the same functions with TRNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA binding | FARSA,ALKBH8,AIMP1,AARSD1,IFIT5,THG1L,TRMT11,RARS,METTL1,EIF2AK4 |
| ATP binding | DSTYK,DQX1,PGK1,KIF2B,PPP2R4,MYH7B,ABCB11,MAP4K2,CSNK1D,EHD2 |
Interacting Protein
TRNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRNT1.
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Resources
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References
- Iolascon, A; et al. Transfer RNA and syndromic sideroblastic anemia. BLOOD 124:2763-2764(2014).
- Chakraborty, PK; Schmitz-Abe, K; et al. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). BLOOD 124:2867-2871(2014).
