TRIM8
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Official Full Name
tripartite motif containing 8 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. -
Synonyms
TRIM8;tripartite motif containing 8;ring finger protein 27 , RNF27, tripartite motif containing 8;probable E3 ubiquitin-protein ligase TRIM8;GERP;glioblastoma expressed ring finger protein;AA408830;BB006755;Lioblastoma expressed ring finger protein;Ring finger protein 27;RNF27;RP11-47A8.4;Tripartite motif protein TRIM8;tripartite motif-containing 8;tripartite motif-containing protein 8;glioblastoma-expressed RING finger protein
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TRIM8 involved in several pathways and played different roles in them. We selected most pathways TRIM8 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interferon gamma signaling | TRIM6,FCGR1B,TRIM68,IRF4,TRIM22,TRIM14,GBP1,TRIM17,GBP2,TRIM2 |
| Interferon Signaling | USP18,TRIM10,TRIM14,SAMHD1,ADAR,IFIT10,IFITM3,IFIT2,IFI30,EIF4G2 |
| Immune System | ASB6,SEC23A,DTX3L,OSCAR,EVL,DEFB103A,SPSB2,PANX1A,CFHL1,LGALS3 |
| Cytokine Signaling in Immune system | IFIT8,PRLRB,FGF8B,IL1RN,PELI3,TRIM14,PHB,IRF9,TRIM68,TRIM17 |
Protein Function
TRIM8 has several biochemical functions, for example, identical protein binding,ligase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM8 itself. We selected most functions TRIM8 had, and list some proteins which have the same functions with TRIM8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | UBE4B,UBE2L3A,ITCH,BIRC7,ZNRF3,SH3RF2,TRIM21,DTX4,NHLRC1,MGRN1 |
| protein homodimerization activity | PRLR,CAMK2A,ERCC5,TAP1,ATP2A1,GCH1,KCNK3,HPGD,DRD2,NR6A1A |
| zinc ion binding | AQPEP,PRKCG,RFPL3,NEIL3,MUL1,SHPRH,LHX1A,THRA,TRIM15,LIMCH1A |
| identical protein binding | TRIM39,PIK3AP1,ITGA2B,DLC,STXBP1,RAD51,SDK2,TRIM21,ACY3,CLDN15 |
Interacting Protein
TRIM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM8.
TRAF5;UBE2L6;TRIM24;RNF113A;TRIM27;TRIM21;CBL;UBE2D1;CCNH;UBE2D3;UBE2D2;XIAP;MKRN3;UBE2V1;TRIM25;recN;RNF111
Resources
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References
- Caratozzolo, MF; Valletti, A; et al. TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma. ONCOTARGET 5:7446-7457(2014).
- Engstrom, KS; Hossain, MB; et al. Efficient Arsenic Metabolism - The AS3MT Haplotype Is Associated with DNA Methylation and Expression of Multiple Genes Around AS3MT. PLOS ONE 8:-(2013).
