TRIM68
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Official Full Name
tripartite motif containing 68 -
Overview
This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. -
Synonyms
TRIM68;tripartite motif containing 68;ring finger protein 137 , RNF137, tripartite motif containing 68;E3 ubiquitin-protein ligase TRIM68;FLJ10369;SS 56;MGC126176;RING finger protein 137;RNF 137;RNF137;Ro/SSA1 related protein;SS56;SSA protein SS 56;TRIM 68;Tripartite motif containing protein 68;SSA protein SS-56;OTTHUMP00000230828;OTTHUMP00000230830;tripartite motif-containing 68;tripartite motif-containing protein 68;GC109;SS-56
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- His
- Non
- GST
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
TRIM68 involved in several pathways and played different roles in them. We selected most pathways TRIM68 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM68 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interferon Signaling | TRIM45,OASL,TRIM38,ARIH1,EIF4E3,HLA-DQB2,GBP1,IRF9,IRF4,TRIM46 |
| Immune System | OSBPL1A,BFB,Siglece,BST2,MGC174155,TRIM5,TLR10,C1rb,TNFSF13B,SOCS3A |
| Interferon gamma signaling | TRIM46,TRIM14,IRF6,TRIM10,IRF4,IFI30,TRIM31,TRIM8,GBP5,TRIM38 |
| Cytokine Signaling in Immune system | FGF20A,IFITM2,CRK,EIF4E,TRIM17,CSK,OASL,ARIH1L,EIF4E3,IFI27 |
Protein Function
TRIM68 has several biochemical functions, for example, androgen receptor binding,histone acetyltransferase binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM68 itself. We selected most functions TRIM68 had, and list some proteins which have the same functions with TRIM68. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| androgen receptor binding | Ar,TCF21,CDK7,DAXX,PARK7,KDM4C,DDX5,TGFB1I1,FHL2,NCOA4 |
| ubiquitin-protein transferase activity | MUL1B,UBE2S,UBA1,RNF181,ZER1,CBL,TRIM5,RNF38,PJA2,HERC2 |
| zinc ion binding | NR3C1,XAF1,RBM10,PCGF5A,RBM14A,CUL9,PEX10,MT1A,DTNA,MMP15 |
| ligase activity | KCNG4,RNF13,RNF182,RAD18,STUB1,MARCH2,UBE4B,RNF217,AMFR,CNOT4 |
| histone acetyltransferase binding | MTF1,TAF7L,ETS1,GLI3,PCNA,SIRT2,NR4A3,MEF2A,CEBPB,CITED2 |
Interacting Protein
TRIM68 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM68 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM68.
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