TRIM6

  • Official Full Name

    tripartite motif containing 6

  • Overview

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members.

  • Synonyms

    TRIM6;tripartite motif containing 6;tripartite motif-containing protein 6;RNF89;Ring Finger Protein 89;TRIM 6;Tripartite motif containing protein 6;tripartite motif-containing 6

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • GST
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRIM6-3415H Recombinant Human TRIM6, GST-tagged E.coli Human GST C-term-300aa
TRIM6-17386M Recombinant Mouse TRIM6 Protein Mammalian Cell Mouse His
TRIM6-765HCL Recombinant Human TRIM6 293 Cell Lysate HEK293 Human Non
TRIM6-3918H Recombinant Human TRIM6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Trim6-6661M Recombinant Mouse Trim6 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
TRIM6-9617M Recombinant Mouse TRIM6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
TRIM6-9617M-B Recombinant Mouse TRIM6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TRIM6 involved in several pathways and played different roles in them. We selected most pathways TRIM6 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system IFIT2,TRIM17,IFIT10,NUP50,NUPL2,PELI3,PTPRA,NRG2A,HLA-DQB2,SPTA1
    Interferon Signaling IFI35,GBP6,ARIH1,TRIM29,TRIM14,IFITM3,GBP1,TRIM17,IRF2,IFIT12
    Interferon gamma signaling GBP1,GBP6,IFI30,TRIM46,TRIM22,TRIM2,HLA-DQB2,OASL,GBP2,TRIM48
    Immune System IRF6,CD200,TRIM41,KLC3,BTLA,RAP1GAP2B,KIR2DS2,BTR30,NCKIPSD,AP1M2

    Protein Function

    TRIM6 has several biochemical functions, for example, ligase activity,molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM6 itself. We selected most functions TRIM6 had, and list some proteins which have the same functions with TRIM6. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity TRIP12,UFL1,PPIL2,MIB2,MARCH9,RNF135,DTX3L,RNF168,MARCH1,MKRN3
    protein kinase binding MAP3K5,CCNK,THY1,HDAC7A,IL31RA,TNIP2,FOXO3,CDK5RAP2,RHOD,FAF1
    molecular_function RTDR1,MBTD1,C21orf56,DEFB121,LENG1,NRSN2,EMC10,GM12942,MARCH11,GSDMC3
    protein binding CUTC,C21orf56,ING2,GIP,CD200R3,POLR3GL,EIF4EBP3,SCO2,DISC1,TAP1
    ubiquitin protein ligase activity MDM2,RNF115,CBLC,ARIH1,RNF7,TRIM59,TRIM2,UBR3,TRIP12,G2E3
    zinc ion binding APOBEC3H,SOD3A,WBP7,BTR30,ZCCHC2,ZDHHC13,JHDM1D,ZFP326,RFPL1,ANAPC11
    transcription factor binding CREG1,MAPK9,JUNBB,REST,KLF5,IFT172,JUND,NAAA,FOXA1,TAF12
    protein binding, bridging TNNT2A,COL8A2,ADAP2,STX1A,NEFH,LOR,SH2D1B,DSP,CBX5,FRMD4A

    Interacting Protein

    TRIM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM6.

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