TRIM5
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Official Full Name
tripartite motif containing 5 -
Overview
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
TRIM5;tripartite motif containing 5;tripartite motif-containing protein 5;RNF88;TRIM5alpha;tripartite motif protein TRIM;tripartite motif protein TRIM5;ring finger protein 88;tripartite motif containing 5 transcript variant iota;tripartite motif
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- His
- Non
- His&Fc&Avi
- His&B2M
Involved Pathway
TRIM5 involved in several pathways and played different roles in them. We selected most pathways TRIM5 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | AP1G1,ATP6V1G3,HBL3,TRIM2,RIPK3,NCR3LG1,FBXO44,GBP6,GZMM,TREML1 |
| Interferon gamma signaling | FCGR1B,TRIM3,TRIM45,TRIM62,GBP5,GBP2,TRIM10,TRIM68,HLA-DQB2,GBP1 |
| Cytokine Signaling in Immune system | TRIM22,GHRB,KBTBD7,DAB2IPB,CASPB,EDAR,PHB,DUSP6,IRF9,DUSP1 |
| Interferon Signaling | IFI30,TRIM26,SAMHD1,IRF9,TRIM10,TRIM38,ADAR,USP18,IFIT2,IFITM3 |
Protein Function
TRIM5 has several biochemical functions, for example, identical protein binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM5 itself. We selected most functions TRIM5 had, and list some proteins which have the same functions with TRIM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | CEACAM5,STK4,HMOX1,UNC13A,LGALS1,UGT1A4,IZUMO3,BNIP3L,GSTM7,VOX |
| ubiquitin-protein transferase activity | FBXO11,RNF38,AMFR,UBE2T,CNOT4,ARIH1L,LMO7,ARIH1,MARCH8,RNF139 |
| protein kinase binding | PARK2,CACNB4,VRK2,TCF7L2,DOK7,GRIN2A,CSPG4,FAM83A,MAP2K6,SPRED2 |
| protein binding, bridging | CAV2,STX1A,PSMC6,SYNM,DSP,RBM14,BCL3,TRIM17,FGG,FSCN2B |
| identical protein binding | USP4,SERPINA1A,MDM2,CD28,LCP1,ACY3,HCN2,E2F7,P2RX6,CALHM1 |
| signaling pattern recognition receptor activity | COLEC12,CLEC7A,TLR2,FCN1,MARCO,DMBT1 |
| ligase activity | UHRF1,PARK2,RBBP6,TRIM69,TRIM68,NSMCE2,MYLIP,MID1,UBOX5,E4F1 |
| protein binding | ERCC6L,FBXO34,CLIC1,TMEM132D,FXYD6,FAM108A1,SLC22A3,CCDC12,SUV39H1,DLAT |
| zinc ion binding | LTN1,ADAMTS9,TRIM25,MMP28,LONRF3,PRICKLE1,EDEM3,PMPCB,PML,PTPN1 |
Interacting Protein
TRIM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM5.
TRIM32;ZWINT;SNAI1;HIP2;UBE2D1;MNAT1;UBE2D3;UBE2N;UBE2H;MKRN3;UBE2V1;UBE2V2;UBE2U;TRIM34
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References
- Ferguson, D; Mattiuzzo, G; et al. Early Biodistribution and Persistence of a Protective Live Attenuated SIV Vaccine Elicits Localised Innate Responses in Multiple Lymphoid Tissues. PLOS ONE 9:-(2014).
- Schneider, A; Wagner, A; et al. Problems and Prospects of Gene Therapy Against HIV. PHARMACEUTICAL CHEMISTRY JOURNAL 47:627-635(2014).
