TRIM33
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Official Full Name
tripartite motif containing 33 -
Overview
The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
TRIM33;tripartite motif containing 33;ECTO;PTC7;RFG7;TF1G;TIF1G;TIFGAMMA;TIF1GAMMA;E3 ubiquitin-protein ligase TRIM33;TIF1-gamma;protein Rfg7;ectodermin homolog;RET-fused gene 7 protein;tripartite motif-containing 33;transcriptional intermediary factor 1 gamma
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- Flag
- His
- GST
- Non
- Twin Strep
- Avi
- Fc
- DDK
- Myc
Involved Pathway
TRIM33 involved in several pathways and played different roles in them. We selected most pathways TRIM33 participated on our site, such as Downregulation of SMAD2/3:SMAD4 transcriptional activity,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | EIF1AX,COX6B1,POP4,LSM11,ZNF398,ZNF597,HNRNPR,CDK8,ZNF621,ESR2A |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | SKIA,SMAD3B,SKI,PARP1,USP9,SKIB,RNF111,USP9X,SKILB |
| Generic Transcription Pathway | ZNF468,NR1D2,TBX5A,ZNF543,ZNF496,NR2F1B,ZNF334,ZNF454,RRAGB,ZFP2 |
| Signaling by TGF-beta Receptor Complex | SKILB,USP15,NEDD8L,PMEPA1,USP9X,STRAP,SKIB,CGNB,SKIA,USP9 |
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | USP9X,SKIB,SKILB,USP9 |
| Signal Transduction | DNAL4A,ZNRF3,NCKIPSD,KREMEN1,DACT1,PMEPA1,SPRY1,STARD8,STAM2,GDI2 |
Protein Function
TRIM33 has several biochemical functions, for example, DNA binding,R-SMAD binding,co-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM33 itself. We selected most functions TRIM33 had, and list some proteins which have the same functions with TRIM33. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | BTR06,LMO7,CPB2,PML,KDM4A,PTPN1,UHRF2,TRIP6,RNF43,RC3H1 |
| ligase activity | RNF181,IRF2BP1,RNF5,MARCH9,SYVN1,MSL2,ZFP91,RNF126,GLULA,TTLL9 |
| DNA binding | HOXA2B,WRN,TBX24,ARID3C,ATXN1L,POLR3K,ZMAT4,ARNTL1B,ZNF324,ENO1 |
| R-SMAD binding | SMURF1,SMAD3,SMAD4,JUN,C18orf1,PAX6,MEN1,MYOCD,ZC3H3,CTNNB1 |
| protein binding | ARHGEF1,UTP14A,TP53,SMG9,DDIT4L,ZBP1,SHPRH,TTYH2,SPACA3,DSC2 |
| ubiquitin-protein transferase activity | LNX2B,FBXO7,FBXL14A,FBXL3,NHLRC1,PRKCQ,CNOT4B,UBR5,UBR1,MUL1B |
| co-SMAD binding | SMAD6,CITED1,USP9X,SMAD1,GATA4,TGIF1,FOXH1,SMAD2,SMAD3 |
Interacting Protein
TRIM33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM33 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM33.
SMAD4;SMAD2;gata1_human_gene;gata2_human_gene;TAL1;CDK9
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