TRD@
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Official Full Name
T cell receptor delta locus -
Overview
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes (or T cells) that is, in general, responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen is of relatively low affinity and is degenerate: that is, many TCR recognize the same antigen and many antigen are recognized by the same TCR.The TCR is composed of two different protein chains (that is, it is a heterodimer). In 95% of T cells, this consists of an alpha (α) and beta (β) chain, whereas in 5% of T cells this consists of gamma and delta (γ/δ) chains.When the TCR engages with antigen and MHC, the T lymphocyte is activated through a series of biochemical events mediated by associated enzymes, co-receptors, specialized accessory molecules, and activated or released transcription factors. -
Synonyms
T cell receptor delta locus;TRD@;TRD;TCRD;TCRDV1;FLJ52034;FLJ52576;FLJ53668;FLJ54555;FLJ55265;FLJ56790;T-cell receptor, delta (V,D,J,C);T-cell antigen receptor, delta polypeptide;T-Cell Receptor Pan gamma
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Involved Pathway
TRD@ involved in several pathways and played different roles in them. We selected most pathways TRD@ participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TRD@ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein Function
TRD@ has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TRD@ itself. We selected most functions TRD@ had, and list some proteins which have the same functions with TRD@. You can find most of the proteins on our site.
Function | Related Protein |
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Interacting Protein
TRD@ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRD@ here. Most of them are supplied by our site. Hope this information will be useful for your research of TRD@.
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References
- Silva, PRB; Moraes, JGN; et al. Effects of weekly regrouping of prepartum dairy cows on innate immune response and antibody concentration. JOURNAL OF DAIRY SCIENCE 96:7649-7657(2013).
- Antonacci, R; Mineccia, M; et al. Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation. MOLECULAR IMMUNOLOGY 48:1384-1396(2011).