TRAF7
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Official Full Name
TNF receptor-associated factor 7 -
Overview
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding. -
Synonyms
TRAF7;TNF receptor-associated factor 7;RFWD1, ring finger and WD repeat domain 1;E3 ubiquitin-protein ligase TRAF7;DKFZp586I021;MGC7807;RNF119;E3 ubiquitin protein ligase TRAF7;RFWD1;Ring finger and WD repeat domain 1;RING finger protein 119;TNF receptor associated factor 7;RING finger and WD repeat-containing protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRAF7-1903C | Recombinant Chicken TRAF7 | Mammalian Cells | Chicken | His |
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| TRAF7-4935R | Recombinant Rhesus monkey TRAF7 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| TRAF7-5042Z | Recombinant Zebrafish TRAF7 | Mammalian Cells | Zebrafish | His |
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| TRAF7-816HCL | Recombinant Human TRAF7 293 Cell Lysate | HEK293 | Human | Non |
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| TRAF7-4749R | Recombinant Rhesus Macaque TRAF7 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| TRAF7-4749R-B | Recombinant Rhesus Macaque TRAF7 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
TRAF7 involved in several pathways and played different roles in them. We selected most pathways TRAF7 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome degradation | RBCK1,RNF14,LRR1,UBE2F,VPRBP,FBXO44,UBE2J2,LTN1,DTX3L,FBXO3 |
| Class I MHC mediated antigen processing & | SH3RF1,SEC24A,B2ML,ASB9,FBXO3,ERAP1,RNF34,CTSL2,TRIM9,WWP1 |
| presentation | ASB14,RNF111,ASB9,RNF34,RNF6,UBE2V2,UBA5,PJA1,CD207,RNF123 |
| Antigen processing: Ubiquitination & | KLHL21,RNF25,UBE2F,DTX3L,KLHL20,UBE2L6,TRIM11,RNF19B,BLMH,CMTM2A |
| Adaptive Immune System | IGHM,CD300A,PDPK1A,RNF138,B2ML,DCTN1,CD300LH,SPTBN2,FRS2A,WWP1 |
| Immune System | KIF22,TRIM22,TRIM6,GRAP2A,KLRG1,SIGLEC11,FCN1,KIF3C,ASB6,KLRB1A |
Protein Function
TRAF7 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF7 itself. We selected most functions TRAF7 had, and list some proteins which have the same functions with TRAF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | LNX2A,TRIM7,NR1D4A,FHL3,MBD1,ALKBH8,ADAM8,TRAF1,ZDHHC14,GCH2 |
| ligase activity | PPIL2,HECTD1,NHLRC1,TRIM17,UBE2D1B,UNKL,RNF19B,ZNRF2,TRIM68,ITCH |
| ubiquitin-protein transferase activity | SHPRH,TRAF5,RNF6,FBXO4,ARIH1,BIRC5B,UBE2A,BIRC5,MDM2,TRIM56 |
| protein binding | AEN,TTC23L,SAFB,CBFA2T3,MYBPHL,CHTOP,STON2,IMPA2,HIST1H2AH,CCND3 |
Interacting Protein
TRAF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF7.
MAP3K3;Ripk4;HIP2;UBE2L6;UBE2D1;UBE2D2;UBE2L3;ampS;UBE2D4;MAP3K2
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